NCT04529655已完成不适用
Digital Capillary Refill for Monitoring of Sepsis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Blood lactate Level
研究概览
简要总结
Observational study for monitoring of capillary refill time in sepsis
详细描述
This is an observational studying assessing changes in capillary refill time over the course of sepsis treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical evidence of a known or suspected infection and orders written for administration of IV antibiotics
- •Hypotension as defined by the need for any vasopressor (and 1 liter of fluid already administered) OR respiratory failure defined by assisted ventilation (includes mechanical ventilation and BIPAP), CPAP, or greater than or equal to 6 liters/minute of supplemental oxygen
排除标准
- •No consent/inability to obtain consent from the participant or a legally authorized representative
- •Diagnosis of cirrhosis by medical chart review
- •Liver transplant recipient
- •AST or ALT greater than five times upper limit of normal
- •Diagnosis of ongoing chronic alcohol use disorder/abuse by chart review; if medical record unclear, use Appendix F
- •Clinical diagnosis of diabetic ketoacidosis or other condition such as profound hypoglycemia that requires hourly blood glucose monitoring
- •Hypersensitivity to Acetaminophen or Vitamin C
- •Patient, surrogate or physician not committed to full support (Exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest)
- •Home assisted ventilation (via tracheotomy or noninvasive) except for CPAP/BIPAP used only for sleep-disordered breathing
- •Current active kidney stone
- •Known history of oxalate kidney stones or history of oxalate nephropathy
- •Kidney transplant recipient
- •Use of home oxygen for chronic cardiopulmonary disease
- •Moribund patient not expected to survive 24 hours
- •Underlying malignancy or other condition with estimated life expectancy of less than 1 month
- •Pregnant woman, woman of childbearing potential without a documented negative urine or serum pregnancy test during the current hospitalization, or woman who is breast feeding
- •Enrollment in another critical care based pharmacologic interventional trial
- •Treating team unwilling to enroll because of intended use of Acetaminophen or Vitamin C
结局指标
主要结局
Blood lactate Level
时间窗: during procedure
Correlation of Capillary refill to blood lactate
次要结局
- 28 day hospital mortality(28 days)
- Vasoactive(24 hours)
研究者
Dr. David Sheridan
Assistant Professor of Emergency Medicine
Oregon Health and Science University
研究点 (1)
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