Role of Anticoagulation in the Management of Tumor Thrombus
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 1,900
- 试验地点
- 1
- 主要终点
- Anticoagulation or vascular intervention
研究概览
简要总结
The purpose of this study is to conduct a retrospective review of oncology patients with a diagnosis of any solid tumor and lymphoma to identify a cohort with radiographically reported tumor thrombus or tumor compression of vasculature. Clinical and radiographic data will be collected on this cohort to understand the incidence and management of tumor thrombus or vascular compression, as well as relevant clinical outcomes, including bleeding, thrombus extension or embolism, and mortality.
详细描述
Identify and characterize (by clinical, demographic, and radiographic data) pediatric and AYA solid tumor oncology patients with radiographic evidence of tumor thrombus.
Assess clinical outcomes (bleeding, thrombus resolution, thrombus extension or embolization, and mortality related to anticoagulation treatment vs non-treatment of identified tumor thrombus.
Identify and characterize pediatric and AYA solid tumor patients with a tumor compressing a vascular structure without thrombosis, as identified by review of radiographic reports.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 0 Months 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All Cincinnati Children's Hospital Medical Center (CCHMC) Oncology patients in the cancer registries (ACCRN07 CCHMC IRB #2008-1609 and the COG Registry CCHMC IRB # 2019-0616) identified as having a solid tumor and lymphoma (including osteosarcoma, Ewing sarcoma, Wilms tumor, hepatoblastoma, neuroblastoma, Hodgkin's and non-Hodgkin's lymphoma) diagnosis, and who, on review of radiographic study reports, have mention of tumor thrombus or vascular compression since January 01, 2010 - January 01, 2026, between the ages of 0 and 40 years old.
排除标准
- •Cancer diagnosis other than a lymphoma or solid tumor Absence of tumor thrombus or vascular compression mentioned in radiographic reports stored at CCHMC (EPIC © 2020 Epic Systems Corporation). Lack of medical records available at CCHMC for review
结局指标
主要结局
Anticoagulation or vascular intervention
时间窗: Baseline through study completion, an average of 1 year
Documentation in medical record of patient being placed on prophylactic or therapeutic anticoagulation or requiring therapeutic intervention (such as thrombectomy graft, stent, thrombolysis, or venoplasty)
Clinical bleeding event
时间窗: Baseline through study completion, an average of 1 year
Major and clinically relevant non-major bleeding per ISTH definition
Thrombus extension
时间窗: Baseline through study completion, an average of 1 year
Documented episode of thrombus extension or embolism, or bland thrombus formation
次要结局
- Disease status at last follow up(Baseline through study completion, an average of 1 year)
- Stage of oncologic disease at diagnosis(Baseline through study completion, an average of 1 year)
- New vs relapsed oncologic disease(Baseline through study completion, an average of 1 year)