High Fresh Gas Flow After Intubation - A Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Atelectasis
研究概览
简要总结
Atelectasis is common during and after general anesthesia. Atelectasis develops early if preoxygenation with 100% oxygen is used and continuously used during induction until endotracheal intubation. The investigators hypothesize that a rapid anti-preoxygenation maneuver immediately after confirming a successful intubation, reduces the area of atelectasis as investigated by computed tomography compared to a standard procedure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy patients, American Society of Anesthesiology (ASA) I-II
- •Patients scheduled for orthopaedic day case surgery in general anaesthesia
排除标准
- •ASA class III or higher
- •Body Mass Index (BMI) 30 or higher
- •Arterial oxygen saturation (SpO2) <94% breathing air
- •Chronic Obstructive Pulmonary Disease (COPD)
- •Ischemic heart disease
- •Haemoglobin <100g/L
- •Known or anticipated difficult airway and/or intubation
- •Active smokers and ex-smokers with a history of more than 6 pack years
- •Need for interscalene or supraclavicular regional anaesthesia with risk of phrenic nerve paralysis
研究组 & 干预措施
Control group, conventional ventilatory settings
Handling of the airway during induction and intubation is performed in a conventional manner.
Initial ventilatory settings are also done in a conventional manner.
干预措施: Control group, conventional ventilatory settings (Procedure)
High fresh gas flow, high minute ventilation
Handling of the airway during induction and intubation is performed in a conventional manner.
Immediately after confirming a successful intubation the effect of preoxygenation is eliminated with an anti-preoxygenation maneuver.
干预措施: High fresh gas flow, high minute ventilation (Procedure)
结局指标
主要结局
Atelectasis
时间窗: Within 1-2 hours, just before emergence from anesthesia
The area of atelectasis in the lungs is assessed by computed tomography (CT) 10 mm above the dome of the right diaphragm and expressed in cm2 and as % of the total lung area in the particular scan.
次要结局
- Arterial blood gases(Within 2-3 hours perioperatively)