Walking, Brain and Functional Magnetic Resonance Imaging Study of Motor Representations in Healthy Subjects and Amnestic MCI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 97
- 试验地点
- 1
- 主要终点
- Review and compare mapping cerebral activation in brain MRI
研究概览
简要总结
Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.
详细描述
Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (<40 years and> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Obtaining the signature of consent to participation in the study
- •Age above 18 years
- •Lack dementia as NICDS-ADRDA criteria
- •Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI).
- •Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae.
- •No cons-indication for performing a brain MRI.
- •Witennses, population of young (<40 years)
- •Witnesses ,population of older subjects (> 60 years)
- •Witnesses Lack of MCI
- •MCI patients, criteria MCI criteria according to Dubois
- •Exclusion Criteria :
- •Refusal of MRI.
- •Contraindications to brain MRI.
排除标准
- 未提供
结局指标
主要结局
Review and compare mapping cerebral activation in brain MRI
时间窗: One day
Review and compare mapping brain activation in healthy about MRI according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination the walk. The primary endpoint is the analysis of fMRI brain mapping in accordance with the different paradigms of acquisition. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters.
次要结局
- Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking.(One day)
- Study of differences in terms of activation of brain mapping(One day)
- study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI.(One day)
- study of the potential effects on muscle activation, and autonomic nervous system(One day)