NL-OMON37368已完成2 期
Effects of levosimendan on diaphragm function in mechanically ventilated patients - Levosimendan in mechanically ventilated patients
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 42 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 42
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •age >18 year
- •mechanical ventilation for at least 3 days
- •PaO2/FiO2 ratio >200 mmHg
- •Ventilatory settings: Positive End Expiratory Pressure <=10 cmH2O, Pressure Support <= 10 cmH2O.
排除标准
- •pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including auto-immune diseases.
- •pre-existent cardiac disease (based on history, electrocardiography and transthoracic echocardiography)
- •upper airway / esophageal pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia)
- •phrenic nerve lesions
- •pregnancy, breast feeding
- •severe renal failure (serum creatinine > 450 µmol/L)
- •severe hepatic failure
- •recent (within 5 days) nasal bleeding
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