Can Chinese Calligraphy Writing Enhance Cognitive Performance and Emotional Calmness in Older Adults With Mild Cognitive Impairment? A RCT Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 99
- 试验地点
- 1
- 主要终点
- Change in Digit span backward test (DSB) from baseline, after end of training, and 6-month follow-up.
研究概览
简要总结
This study is aimed to investigate the efficacy of an 12-week Chinese calligraphy training program for enhancing cognitive and emotional functions of older adults with mild cognitive impairment. Participants are tested with several cognitive tests and electroencephalography (EEG), psycho-physical parameters and brain activities are recorded. Results are compared at pre-intervention, post-intervention, and 6-month post-intervention to provide evidence of benefits of Chinese calligraphy practice.
详细描述
Participants are older adults with mild cognitive impairment, who will be recruited from several community elderly centers in Hong Kong according to selective criteria. The participants are randomly assigned to an experimental or a control group. The experimental group is invited to participate in 16 sessions of structured Chinese calligraphy program over 12 weeks. Each session lasts for 1.5 hours. The control group is invited to participate in an iPad learning program with navigating the Internet. The iPad program is also consisted of 16 sessions of 1.5 hours each over 8 weeks. Cognitive tests and physiological measures are conducted immediately before and after intervention and at 6-month post-intervention follow-up. Statistical analysis are performed to investigate the significant differences and interactions among the three time points. The association of cognitive performance and emotional calmness is also investigated.
Selected participants are invited to take part in a EEG session while doing some computer tasks related to Chinese calligraphy. EEG results of are used to explore neural activities associated with visuospatial working memory and to provide evidence for neural changes at functional level as a result of Chinese calligraphy training and practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meeting Petersen's criteria for mild cognitive impairment
- •Being able to read simple Chinese characters
- •Community-dwelling
- •Clinical Dementia Rating score of 0.5
- •No substantial prior experience of calligraphy writing
- •Willing to write using a brush and willing to participate
排除标准
- •Presence of musculoskeletal problems preventing participants from writing
- •Known chronic cardiovascular (e.g. systolic BP > 140mmHg) or pulmonary conditions requiring long-term medication
- •Presence of severe mental disorder such as psychosis or depression.
研究组 & 干预措施
Calligraphy Training
This group receives a Chinese calligraphy training program of 16 sessions over 8 weeks in a class of 8-12 participants. Each session is 1.5 hours.
干预措施: Calligraphy Training (Behavioral)
iPad Training
This group receives an iPad training program of 16 sessions over 8 weeks in a class of 8-12 participants. Each session is 1.5 hours.
干预措施: iPad Training (Behavioral)
结局指标
主要结局
Change in Digit span backward test (DSB) from baseline, after end of training, and 6-month follow-up.
时间窗: Baseline, within 2 weeks after end of training, and 6-month follow-up.
DSB evaluates working memory, which requires recalling digits in reverse order. The DSB test is structured with increased levels of difficulty.
次要结局
- Color Trails Test (CTT)(Baseline, within 2 weeks after end of training, and 6-month follow-up.)
- Blood pressure.(At the week 1, 5, 9, 12 during the intervention period, and at 6-month post-intervention.)
- Heart rate and heart rate variability.(At the week 1, 5, 9, 12 during the intervention period, and at 6-month post-intervention.)
- Symbol-digit Modalities Test (SDMT)(Baseline, within 2 weeks after end of training, and 6-month follow-up.)
- Geriatric Depression Scale - Short Form (GDS-SF)(Baseline, within 2 weeks after end of training, and 6-month post-intervention.)
- Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB)(Baseline, within 2 weeks after end of training, and 6-month post-intervention.)
研究者
Prof. Chetwyn Chan
Associate Vice President (Learning and Teaching) and Chair Professor
The Hong Kong Polytechnic University