NCT01483339已完成不适用
Metacognitive Therapy Versus Exposition With Response Prevention for Patients With Obsessive-Compulsive Disorder
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- Change in Symptom Severity (Yale Brown Obsessive-Compulsive Scale; YBOCS) from Pretest to Posttest to Follow-up
研究概览
简要总结
Cognitive behavior therapy is the most effective treatment of obsessive-compulsive disorder. However, the majority of treated patients remain symptomatic. The metacognitive therapy by Wells (1997) could achieve substantial gains in first pilot studies. The purpose of this study is to investigate this approach with a randomized controlled trial by comparing metacognitive therapy with exposure and response prevention for obsessive-compulsive disorder.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary diagnosis: obsessive-compulsive disorder
- •German-speaking
- •Agreeing to participate, verified by completion of informed consent
排除标准
- •Current or past diagnosis of substance dependence, psychosis, neurological conditions
- •Mental retardation
研究组 & 干预措施
Metacognitive Therapy
Experimental
干预措施: Metacognitive Therapy (Behavioral)
Exposure and Response Prevention
Experimental
干预措施: Exposure and Response Prevention (Behavioral)
结局指标
主要结局
Change in Symptom Severity (Yale Brown Obsessive-Compulsive Scale; YBOCS) from Pretest to Posttest to Follow-up
时间窗: from Pretest (admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission)
次要结局
- Change in Metacognitions from Pretest to two in-between timepoints to Posttest to Follow-up(from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission))
- Change in Behavioral Avoidance (Behavioral Avoidance Test, BAT) from Pretest to two in-between timepoints to Posttest to Follow-up(from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission))
- Treatment expectancy (Treatment Expectancy Questionnaire) after the first treatment session(after the first treatment session (an expected average of 1 week after admission))
- Change in Symptom Severity (Padua Inventory; PI) from Pretest to two in-between timepoints to Posttest to Follow-up(from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission))
- Change in Symptom Severity (Clinical Global Impressions; CGI) from Pretest to two in-between timepoints to Posttest to Follow-up(from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission))
- Change in Obsessive Beliefs (Obsessive-Beliefs Questionnaire, OBQ) from Pretest to two in-between timepoints to Posttest to Follow-up(from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission))
- Change in Anxiety (Beck Anxiety Inventory, BAI) from Pretest to Posttest to Follow-up(from Pretest (admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission))
- Change in Patient-Therapist-Alliance from Pretest to two in-between timepoints to Posttest to Follow-up(from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission))
- Satisfaction with the treatment at Posttest(immediately after completion of therapy (an expected average of 3 months after admission))
- Change in Symptom Severity (Obsessive-Compulsive Disorder Scale; OCD-S) measured before every treatment session(from the first treatment session (an expected average of 1 week after admission) to the last treatment session (an expected average of 3 months after admission) on a weekly basis)
- Change in Depression (Beck Depression Inventory, BDI) from Pretest to Posttest to Follow-up(from Pretest (admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission))
研究者
Julia Anna Glombiewski
Principal Investigator
Philipps University Marburg Medical Center
研究点 (2)
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