NL-OMON40196已完成不适用
The Innate Immune System in Atherosclerosis - ISA
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 240
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Group A: 40 Healty control subjects
- •- Aged 18 years or older;Group B: 40 Chronic kidney disease (CKD) patients
- •- Aged 18 years or older
- •- 20 CKD stages 3 and 4 (GFR: 15-60 ml min-1) and
- •- 20 Kidney transplant donors with GFR: 15-60 ml min-1 for a duration of at least 3 months
- •- Non inflamed (CRP <10);Group C: 20 patients with rheumathoid artritis, currently in remission as assessed by disease activity score <2,6
- •- Aged 18 years or older
- •- Non inflamed (CRP <10);Group D: 30 patients with peripheral artery disease defined as: EA-index < 0,9 and validated PAD with echo duplex, divided into 3 groups:
- •- 10 patients without DM2
- •- 10 patients with DM2 on oral glucose lowering therapy only
- •- 10 patients with DM2 on oral glucose lowering therapy and insulin
- •- Aged 18 years or older
- •- Non inflamed (CRP <10);Group E:
- •60 patients with a diagnosis of hypercholesterolemia, consisting of 3 subgroups
- •- 20 subjects currently not on statin therapy
- •- 20 subjects on stable statin therapy (at least 3 months) with LDL levels on target
- •- 20 subjects on stable statin therapy (at least 3 months) with LDL levels not on target
- •- Aged 18 years or older
- •- Non inflamed (CRP <10)
排除标准
- •Exclusion criteria for all subjects
- •- Known malignant disorders or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator.
- •- Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.
- •- Clinical signs of acute infection and/or CRP>10;Exclusion criteria for group B: Chronic Kidney Disease
- •- Diabetic nephropathy
- •- History of MI/Stroke;Exclusion criteria for group C: Rheumatoid artitis
- •- History of MI/Stroke;Exclusion criteria for group D: Peripheral artery disease
- •- MI/Stroke in the last 12 months;Exclusion criteria for group E: Hypercholesterolemia
- •- MI/Stroke in the last 12 months
研究者
相似试验
招募中
不适用
Atherosclerosis and the Innate immune system in patients with Diabetesarterial wall thickening1001842410003216atherosclerosisNL-OMON44284Academisch Medisch Centrum640
已完成
不适用
The innate immune system in atherosclerosis - IIarterial wall thickening10003216atherosclerosisNL-OMON42376Academisch Medisch Centrum340
进行中（未招募）
不适用
Immune Mediators and Metabolites to Stratify Systemic Lupus Erythematosus Patients at High Risk of Cardio Vascular DiseasesSystemic Lupus ErythematosusNCT04276701University Hospital, Bordeaux500
Unknown
不适用
Investigating Atherosclerosis In Seronegative SpondyloarthropathyIn Seronegative SpondyloarthropathyNCT04891783Sohag University120
已完成
不适用
A Study of Immunological Biomarkers as Predictors of Cardiovascular EventsCardiovascular AbnormalitiesNCT02894060Centre Hospitalier Universitaire, Amiens84