Cerebrovascular Autoregulation During Major Non-cardiac Surgery and Risk for Postoperative Cognitive Dysfunction in Elderly Patients
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- Postoperative change of cognitive function from baseline
研究概览
简要总结
Cerebral blood flow is tightly regulated to ensure constant cerebral perfusion independently from systemic blood pressure fluctuations. This mechanism is termed cerebrovascular autoregulation and preserves adequate cerebral perfusion in a range between 50 and 150 mmHg of cerebral perfusion pressure. Upper and lower autoregulatory limits may vary individually. Beyond the autoregulatory range the protective autoregulatory response is lost, facilitating cerebral ischemia or hyperemia.
The cerebrovascular response may be altered during general anesthesia, through direct effects of anesthetic agents on the vascular tone, changes of arterial partial pressure of carbon dioxide or the administration of vasoactive substances. The association of perioperative impairment of cerebral autoregulation and postoperative cognitive function has been discussed controversially.
详细描述
- continuous monitoring of cerebrovascular autoregulation using the correlation method
- based on near-infrared spectroscopy and invasive blood pressure measurement an index (COx) will be calculated
- autoregulation monitoring from anesthesia induction until emergence from anesthesia
- assessment of preoperative cognitive function during preanesthesia evaluation or on the day before surgery
- assessment of postoperative cognitive function between day 3 and 14 following surgery
- evaluation of subjective cognitive complaints or attention deficits 3 months after surgery
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •elective major non-cardiac/non-vascular surgery
- •anticipated surgical duration >120 minutes
- •age >= 60 years
- •indication for invasive blood pressure measurement
- •native German speaker
排除标准
- •history of cerebrovascular disease
- •preexisting cognitive impairment
- •history or presence of neurological disease
结局指标
主要结局
Postoperative change of cognitive function from baseline
时间窗: preoperative psychometric evaluation on the day before surgery, postoperative psychometric evaluation between day 3 and 14 after surgery
change of cognitive function following surgery compared with preoperative cognitive performance, defined as: z-score \<-1.96/\>1.96 in two or more neuropsychological tests (California Verbal Learning Test for verbal learning, Grooved Pegboard Test for visual motoric coordination, Digit Span forward task for attention and memory, Trail-Making-Test A and B for executive function) and/or a combined z-score \>1.96
次要结局
- cognitive failures three months following surgery(three months after elective surgery)