Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Amplitude of Mismatch Negativity (MMN)
研究概览
简要总结
The goal of this observational study is to learn how severe obstructive sleep apnea-hypopnea syndrome (OSAHS) affects the brain's ability to process sounds and attention in adults aged 20-60 years. The main questions it aims to answer are:
- Does severe OSAHS change how the brain automatically detects sound changes during wakefulness?
- Does severe OSAHS reduce people's ability to pay attention to important sounds when awake?
- Can brainwave tests (Electroencephalogram, EEG) detect early signs of hearing-related cognitive problems in OSAHS patients before symptoms appear?
Researchers will compare two groups:
- 50 adults with severe OSAHS (diagnosed by sleep tests)
- 50 healthy adults matched by age and gender
Participants will:
-
Complete hearing tests (MoCA)
-
Undergo a 1-night sleep test (PSG)
-
Wear an EEG cap for 1.5-2 hours while listening to sounds in a quiet room:
-
Passive task: Relax (no response needed)
-
Active task: Press a button when hearing rare sounds
-
Receive ¥75/hour compensation for their time
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All Participants:
- •Aged 20-60 years
- •Normal hearing (PTA ≤25 dB HL at 0.5,1,2,4 kHz; Type A tympanogram)
- •MoCA score ≥26
- •Willing to complete EEG testing
- •OSAHS Group Additional:
- •PSG-confirmed severe OSAHS (AHI >30 events/hour)
- •Control Group Additional:
- •Self-reported absence of snoring/sleep disorders
- •No prior OSAHS diagnosis
排除标准
- •All Participants:
- •History of:
- •Schizophrenia, epilepsy, Parkinson's, TBI, or language disorders
- •Middle/inner ear diseases (otitis media, acoustic neuroma, etc.)
- •Cognitive impairment or depression/anxiety disorders
- •Chronic steroid use
- •Systemic inflammatory diseases or malignancies
- •Pregnancy or suspected pregnancy (self-reported)
结局指标
主要结局
Amplitude of Mismatch Negativity (MMN)
时间窗: Day 1
EEG-derived MMN amplitude (microvolts, μV) during oddball task. Lower values indicate impaired automatic sound change detection.
Latency of Mismatch Negativity (MMN)
时间窗: Day 1
EEG-derived MMN latency (milliseconds, ms) during oddball task. Longer values indicate slower automatic processing.
次要结局
- Accuracy in Active Auditory Oddball Task(Day 1)
- Reaction Time in Active Auditory Oddball Task(Day 1)
- Inter-Trial Phase Coherence (ITPC) in Theta/Alpha/Beta Bands(Day 1)