Auditory Brainstem Evoked Potentials in Autism Spectrum Disorder: A Window on Neural Maturation and Sex Differences
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Differences in BAEP interpeak intervals (I-III, III-V, I-V)
研究概览
简要总结
This retrospective study investigates auditory brainstem evoked potentials (BAEPs) in children with autism spectrum disorder (ASD) compared with other neuropsychiatric conditions. The study aims to evaluate differences in BAEP parameters, with particular attention to sex- and age-related effects and clinical severity
详细描述
Autism spectrum disorder is a neurodevelopmental condition frequently associated with atypical sensory processing, particularly in the auditory domain. BAEPs provide an objective neurophysiological measure of auditory pathway integrity and maturation at the brainstem level.
This study retrospectively analyzes BAEP recordings collected at IRCCS Fondazione Mondino between January 2021 and December 2023. Latencies of waves I, III, and V, as well as interpeak intervals (I-III, III-V, I-V), are compared between children with ASD and children with other neuropsychiatric conditions.
Secondary analyses explore associations between BAEP parameters, ASD severity, age, and sex, in order to clarify potential neurobiological differences and evaluate BAEPs as candidate electrophysiological biomarkers for ASD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 2 Years 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children aged 2-5 years
- •BAEP examination performed at IRCCS Fondazione Mondino between January 2021 and December 2023
- •Diagnosis/Suspicion of autism spectrum disorder or other neuropsychiatric conditions
- •Availability of technically reliable BAEP recordings
排除标准
- •Non-interpretable BAEP recordings due to lack of cooperation
结局指标
主要结局
Differences in BAEP interpeak intervals (I-III, III-V, I-V)
时间窗: Single assessment at admission between 2021 and 2023 (retrospective analysis)
Differences in BAEP interpeak intervals (I-III, III-V, I-V) between children with ASD and other neuropsychiatric conditions
Differences in BAEP wave latencies (I, III, V)
时间窗: Single assessment at admission between 2021 and 2023 (retrospective analysis)
Differences in BAEP wave latencies (I, III, V) and interpeak intervals (I-III, III-V, I-V) between children with ASD and other neuropsychiatric conditions
次要结局
- BAEP parameters and ASD severity(Single assessment at admission between 2021 and 2023 (retrospective analysis))
- BAEP parameters and age(Single assessment at admission between 2021 and 2023 (retrospective analysis))
- BAEP parameters and sex(Single assessment at admission between 2021 and 2023 (retrospective analysis))