Clinical Risk Assessment of Cognitive Function in Systemic Autoimmune Diseases
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Mini-mental State Examination
研究概览
简要总结
Objectives: Systemic autoimmune diseases are chronic diseases characterized by chronic inflammation, vasculopathy, and autoimmune phenomena. Several organ involvements are typical, including the central nervous system. Formerly published investigations emphasize a mild cognitive impairment affecting attention, memory, and complicated solution tasks. However, these symptoms significantly impact patients' routines and quality of life. The study examined the associations between cognitive impairment and clinical parameters regarding systemic autoimmune diseases.
Methods: General clinical data, some serum biomarkers including CCl-18, YKL-40, COMP, VEGF, Galectin-3, and Pentraxin as well as results of functional, quality of life, and neuropsychological measures, the Mini-Mental State Examination (MMSE), the Digit Span Forward-Backward, the Trail making A, B and the Digit Symbol tests all were administered.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systemic autoimmune diseases
- •Healthy individuals - as controls
排除标准
- •Diseases of the central nervous system
- •Presence of pregnancy
结局指标
主要结局
Mini-mental State Examination
时间窗: 12 months
Complex Cognitive measure
The Functional Assessment of Chronic Illness Therapy F
时间窗: 12 months
health-related quality of life measure
次要结局
未报告次要终点
研究者
dr Varjú Cecília
Associate Professor
University of Pecs