Use of Nitric Oxide Metabolites for Predicting Embryo Quality in In-Vitro Fertilization
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- Percentage of subjects with viable pregnancy one month after embryo transfer
研究概览
简要总结
Improvements in In-Vitro Fertilization (IVF) outcomes have largely been due to the generation of excess embryos allowing for multiple embryo transfer. Unfortunately this has also increased the risk of multiple pregnancy with associated maternal and neonatal morbidity and mortality. The investigators believe that the concentration of nitric oxide metabolites measured in the culture medium from the first day of culture can identify the best quality embryos allowing us to transfer a limited number of embryos without compromising the optimum chance for pregnancy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age 21-37
- •Less than two previous unsuccessful IVF cycles
排除标准
- •Day 3 FSH >9.9
- •Fewer than 8 mature oocytes retrieved
- •Fewer than 8 normally fertilized embryos on day 2 after fertilization
研究组 & 干预措施
Day 3 transfer
Subjects in this arm will have two embryos transferred three days after fertilization. Embryos will be selected based on the concentration of nitric oxide metabolites in the culture medium.
干预措施: Transfer of embryos on day 3 or day 5 after fertilization. (Procedure)
Day 5 transfer
Subjects will have two embryos transferred on day 5 after fertilization with selection of embryos based on morphologic criteria.
干预措施: Day 5 transfer (Procedure)
结局指标
主要结局
Percentage of subjects with viable pregnancy one month after embryo transfer
时间窗: 1 month
次要结局
- Percentage of subjects with > 2 viable embryos one month after embryo transfer(1 month)