Effect of Cognitive Stimulation on Recovery After Stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Change in neuropsychological performance (verbal memory)
研究概览
简要总结
Single blind randomized clinical trial including 50 stroke patients to investigate the effect of daily music listening on behavioral, neural and physiological recovery. Patients are randomized (1:1:1) to listen instrumental or vocal music, or audiobooks (recorded book reading) (control). Outcome measures are change in neuropsychological tests, change in self-reported mood, structural and functional magnetic resonance imaging changes and hormonal changes performed at acute, 3-month and 6-month stages.
详细描述
Please see above
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute Hemispheral stroke
排除标准
- •Previous neurological or current psychiatric disease,
- •severe aphasia
研究组 & 干预措施
Instrumental music listening
Daily music listening
干预措施: Music listening (Behavioral)
Vocal music listening
Daily music listening
干预措施: Music listening (Behavioral)
Audiobook listening (control)
Daily audiobook listening
干预措施: Audiobook listening (Behavioral)
结局指标
主要结局
Change in neuropsychological performance (verbal memory)
时间窗: From acute to 6-month-stage
Verbal memory summary score (RBMT story recall, auditory-verbal learning task)
Change in neuropsychological performance (verbal memory)
时间窗: From acute to 3-month-stage
Verbal memory summary score (Rivermead Behavioral Memory Test (RBMT) story recall, auditory-verbal learning task)
次要结局
- Change in neuropsychological performance (Language skill)(From acute to 6-month-stages)
- Change in physiological stress level(From acute to 6-month-stage)
- Change in structural white matter(From acute to 6-month stage)
- Change in structural gray matter(From acute to 3-month-stage)
- Change in structural gray matter changes(From acute to 6-month-stage)
- Change in mood(From acute to 6-month-stage)
- Change in neuronal function(From acute to 6-month stage)
- Change in neuropsychological performance (Language skill)(From acute to 3-month-stage)
- Change in mood(From acute to 3-month-stage)
- Change in structural white matter(From acute to 3-month stage)
- Change in neuronal function(From acute to 3-month stage)
- Change in physiological stress level(From acute to 3-month-stage)