NCT01374594已完成不适用
Importance of Meal Fat Content and Gall Bladder Emptying for Postprandial GLP-1 Secretion in Type 2 Diabetes Patients
University Hospital, Gentofte, Copenhagen1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2011年6月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- GLP-1 secretion
研究概览
简要总结
PURPOSE
The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology.
In the present study the investigators examine the GLP-1 secretion in healthy subjects and in Type 2 Diabetes Mellitus (T2DM) patients. The investigators hypothesize that patients with T2DM of relatively long duration will be characterized by reduced gall bladder emptying, and, consequently, reduced intestinal TGR5 activation; resulting in attenuated postprandial GLP-1 responses (primary endpoint).
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •HbA1 < 6 %
- •Normal haemoglobin levels
- •Informed content
- •Inclusion Criteria: (T2DM)
- •T2DM > 5 years
- •Normal haemoglobin levels
- •Informed content
排除标准
- •Treatment with insulin, DPP-IV inhibitor or GLP-1 analogues
- •Obesity (BMI > 30)
- •Age > 70 years
- •Gastrointestinal disease
- •Nephropathy
- •Liver disease
- •Medication which cannot be on hold for 12h
- •Gastrointestinal surgery
- •Exclusion Criteria: (Healthy)
- •1st degree relatives with diabetes
- •Obesity (BMI > 30)
- •Age > 70 years
- •Gastrointestinal disease
- •Nephropathy
- •Liver disease
- •Medication which cannot be on hold for 12h
- •Gastrointestinal surgery
结局指标
主要结局
GLP-1 secretion
时间窗: Postprandial
次要结局
未报告次要终点
研究者
David P. Sonne
MD
University Hospital, Gentofte, Copenhagen
研究点 (1)
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