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临床试验/NCT05357222
NCT05357222进行中(未招募)不适用

Impact of Vocal Fold Stretching Exercise on Pitch Range and Phonation Stability

University of Utah2 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2021年11月16日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
120
试验地点
2
主要终点
Voice Range Profile (VRP)

研究概览

简要总结

To investigate the change in fundamental frequency range and vocal fold stability achievable with vocal fold stretching exercise in human populations with high and low vocal activity

详细描述

The vocal ligament is part of the layered structure of the vocal fold. It is a thin band of tissue near the superior medial edge of the vocal fold. The cord-like appearance of the ligament gave rise to the traditional term "vocal cord". The ligament connects the arytenoid cartilage (lower broad dark region) to the anterior portion of the thyroid cartilage (upper dark region). The slightly thickened endpoints are known as the anterior and posterior macula flava. In the medial-lateral direction, the vocal ligament comprises the intermediate and deep layer of the lamina propria.

The physiological functions of the vocal ligament are not fully understood. One function is to limit mechanical strain (elongation), a general function of most ligaments in the body. A second function may be to produce a firm closure of the glottis by forming a straight edge along the membranous (vibrating) portion of the vocal fold. A strong ligament that can be tensed with exercise is likely to help straighten the edge of the folds. Vocal fold bowing, for example, is a pathological condition often associated with advanced age, but it can also occur in young adults who press their arytenoid cartilages together excessively in speech. Atrophy of the thyroarytenoid muscle, which lies lateral to the ligament, causes the middle of the membranous vocal fold to be retracted from the midline of the glottis. The result is a weak voice because airflow cannot be suddenly shut off for efficient acoustic excitation of the vocal tract. For self-sustained vocal fold vibration, the superficial layer must be very pliable and deformable for mucosal surface-wave motion. The role of the ligament is then to stabilize the vertical motion when large pressures are applied to vocal fold surfaces. The most important known function of the ligament, however, is to widen the fundamental frequency range. The stiffer the ligament, the greater the likelihood that several octaves of fo range can be achieved.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Participants must be 18 years or older
  • no current voice disorder
  • no history of performance or professional vocal training

排除标准

  • history of head/neck cancer, laryngeal surgery, current voice disorder requiring medical management
  • cognitive limitations that would prevent them from successfully and safely participating in the study.
  • history of gastrointestinal disease or surgery w
  • no known neurological or structural abnormalities of vocal folds
  • previous laryngeal surgeries;
  • allergies to local anesthetics (used to suppress a sensitive gag reflex during laryngeal endoscopic examination);
  • cardiac abnormalities;
  • recent history of smoking (must be completely smoke-free for six months prior to study commencement because of the effect of smoking on the voice and laryngopharyngeal reflux severity).

结局指标

主要结局

Voice Range Profile (VRP)

时间窗: 3 months following intervention

a thorough voice range profile will be created by testing the participants lowest (minimum) and highest (maximum) achievable pitches across a spectrum of vocal intensities (soft, medium and loud).

次要结局

  • Electroglottography (EGG)(3 months following treatment.)
  • Acoustic measurement(3 months following treatment.)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Lynn Maxfield

Research Scientist

University of Utah

研究点 (2)

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