Risk stratification of interstitial lung abnormalities using hyperpolarised xenon MRI and blood biomarkers

Oxford University Hospitals NHS Trust0 个研究点目标入组 60 人开始时间: 2024年8月27日最近更新: 2024年9月9日

适应症

试验速览

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•1.Participant is willing and able to give informed consent for participation in the study.
•2.Male or Female, aged over 18 and under 85 years of age
•3.Investigators are of the opinion that the participant is able and willing to comply with the study requirements
•3.1.Lung function tests that are normal or near normal – FVC and TLCO >70% predicted for age and gender
•3.2.CT imaging fulfils criteria for ILA –
•3.2.1.Incidental identification of non-dependent abnormalities on Chest CT, including ground glass or reticular abnormalities, lung distortion, traction bronchiectasis and honeycombing
•3.2.2.Occupying up to 10% of the lung as agreed independently by two consultant thoracic radiologists

•1.Unable to provide informed consent
•2.Contraindication to MRI e.g. shrapnel injury, heavily tattooed, severe claustrophobia
•3.Any significant disease or disorder which, in the opinion of the investigator, might influence the interpretation of the clinical data e.g. Significant co-pathology (e.g. emphysema, poorly controlled asthma, heart failure, pulmonary thromboembolic disease, Covid-19 condition, pneumotoxic agents resulting in lung damage)
•4.Clinical frailty score of 6 or above
•5.Female participant who is pregnant, lactating or planning pregnancy.

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