The Effect of TMS on Emotional Valence Evaluation of Aversive Pictures
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Emotional valence for aversive pictures
研究概览
简要总结
The goal of the current clinical trial is to investigate whether transcranial magnetic stimulation (TMS) over specific brain areas can influence the perception of emotional images and emotional memory. TMS is a non-invasive superficial brain stimulation generated by a magnetic field. The results of the study aim to provide valuable insights for the use of TMS in the investigation of mental processes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Generally healthy
- •Normotensive (BP 90/60mmHg - 140/90mmHg)
- •BMI: 18 - 30 kg/m2
- •Fluent in speaking German
排除标准
- •Metal in the head area (e.g., splinters, fragments, clips, etc.)
- •Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS)
- •Cardiac pacemaker or intracardiac lines
- •Medication infusion device
- •Non removable metal piercings in the head area, pivot teeth (retainers are no exclusion criterion)
- •Tattoos (head area) less than 3 months old or older than 20 years
- •Condition after neurosurgery
- •Hearing problems or tinnitus
- •Not able to sit still due to tremor, tics, itching
- •History of repeated syncope
- •Head trauma diagnosed as concussion or associated with loss of consciousness
- •diagnosis of epilepsy, or a convulsion or a seizure in the past of the participant or his/her close family (parents and siblings)
- •TMS in the past showing problems
- •Spinal or ventricular derivations
- •Positive pregnancy test
- •Alcohol intake 12 hours before TMS visits
- •Regular intake of any medication (excluding oral contraceptives)
- •CNS-active medication or illegal drugs 48h before TMS visits
- •Individual's rMT above the limits of rTMS device
- •Suicidal tendency as measured by Montgomery-Åsberg Depression Rating Scale (MADRS), item 10 > 0
研究组 & 干预措施
Participants starting with experimental condition
Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex
干预措施: Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation (Device)
Participants starting with experimental condition
Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex
干预措施: Control continuous 30 Hz thetaburst transcranial magnetic stimulation (Device)
Participants starting with control condition
Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex
干预措施: Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation (Device)
Participants starting with control condition
Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex
干预措施: Control continuous 30 Hz thetaburst transcranial magnetic stimulation (Device)
结局指标
主要结局
Emotional valence for aversive pictures
时间窗: Immediately after the intervention, lasting for approximately 7 minutes
The mean valence rating of aversive pictures as assessed by a visual analogue scale assessed directly after TMS.
次要结局
- Emotional arousal(Immediately after the intervention, lasting for approximately 7 minutes)
- Aversive episodic memory(Approximately one hour after the intervention)
研究者
Prof. Dominique de Quervain, MD
Director Division of Cognitive Neuroscience
University of Basel