Effect of Aging and Aerobic Exercise Training on Brain Glucose Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Change in Brain Glucose Uptake
研究概览
简要总结
Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy sedentary adults aged 18-30 or 65-80 years of all ethnicities will be eligible. Pregnant women, children, prisoners or other at risk populations will not be recruited.
- •Inclusion Criteria:
- •Age 18-30 years or 65-80 years
排除标准
- •Body mass index (BMI) >31 kg/m2
- •Pregnancy
- •Participation in structured exercise (>2 times per week for 30 minutes or longer)
- •Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease
- •Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise
- •Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist)
- •Claustrophobia
研究组 & 干预措施
Exercise
Aerobic exercise
干预措施: High intensity aerobic training (Behavioral)
Exercise
Aerobic exercise
干预措施: Sedentary Control (Behavioral)
结局指标
主要结局
Change in Brain Glucose Uptake
时间窗: 12 weeks
The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period.
次要结局
未报告次要终点