NCT05766384招募中不适用
Hyperpolarized 129Xe MRI to Identify Structural Determinants of Low Lung Function and Respiratory Symptoms in Young Adults From the Lung Health Cohort
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 260
- 试验地点
- 12
- 主要终点
- Xe-MRI Apparent Diffusion Coefficient
研究概览
简要总结
A subset of young adults participating in the American Lung Association (ALA) Lung Health Cohort (LHC) will be imaged using Hyperpolarized 129Xe MRI to assess lung structure and function. Images will be used to improve the understanding of lung health and early lung abnormalities that may lead to chronic lung disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Is enrolled in the American Lung Association Lung Health Cohort Study.
- •Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date.
排除标准
- •Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, > 140 cm shoulder circumference, dependent on weight distribution).
- •Is pregnant or breastfeeding
- •Oxygen saturation (SpO2) <88% on room air or with supplemental oxygen.
结局指标
主要结局
Xe-MRI Apparent Diffusion Coefficient
时间窗: At baseline imaging timepoint
Correlation of Xe-MRI with FEV1/FVC and other measures of lung function
次要结局
未报告次要终点
研究者
Peter J. Niedbalski, PhD
Research Assistant Professor
University of Kansas Medical Center
研究点 (12)
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