CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 87
- 试验地点
- 1
- 主要终点
- CT index - RA960 (%)
研究概览
简要总结
Various indexes have been proposed to quantify both pulmonary emphysema and airways disease on chest CT scans. It is unknown whether these indexes should be consider in absolute values or as compared to predicted normal values. The purposes of the present study is thus : a) to measure these indexes at CT in healthy volunteers; b) to investigate their relations with gender, height and weight.
详细描述
87 healthy volunteers performed consecutively a low-dose chest CT scan and pulmonary function tests:
- On chest CT scans, indexes reflecting pulmonary emphysema and airways measurements have been computed by using dedicated softwares. Each of our three readers performed two reading sessions.
Relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units; luminal area and wall thickness in third and fourth generations airways were recorded. 2. Pulmonary function tests were performed: vital capacity, forced vital capacity , functional residual capacity, total lung capacity, residual volume, forced expiratory volume in one second, and diffusion lung capacity for carbon monoxide were recorded (either in absolute values and percentage of predicted values).
CT indexes were compared with gender, height and weight.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Never smoked.
- •No respiratory infection in the 4 weeks before the begin of the study.
- •No history of pulmonary resection.
- •No active malignancy or malignancy of any organ system within the past 5 years.
排除标准
- •no exclusion criteria
结局指标
主要结局
CT index - RA960 (%)
时间窗: 4 hours
From acquired data, images were reconstructed using a soft algorithm. On these soft images, the relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units was computed (expressed in %), as an index representative of pulmonary emphysema extent.
CT index - LA4th (mm2)
时间窗: 4 hours
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in fourth generations of airways (expressed in mm2).
CT index - LA3rd (mm2)
时间窗: 4 hours
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in third generations of airways (expressed in mm2).
CT index - WT4th (mm)
时间窗: 4 hours
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in fourth generations of airways (expressed in mm).
CT index - WT3rd (mm)
时间窗: 4 hours
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in third generations of airways (expressed in mm).
次要结局
- Pulmonary function tests - FRC (l)(4 hours)
- Pulmonary function tests - TLC (l)(4 hours)
- Pulmonary function tests - DLCO (ml/min/ mmHg)(4 hours)
- Pulmonary function tests - VC (l)(4 hours)
- Pulmonary function tests - RV (l)(4 hours)
- Pulmonary function tests - FVC (l)(4 hours)
- Pulmonary function tests - FEV1 (l)(4 hours)