Liver Function and Inflammation in Obese Postmenopausal Women: Responses to Moderate Intensity Intermittent Walking
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Alanine transaminase
研究概览
简要总结
The goal of this clinical trial is to investigate the impact of a walking training intervention program on liver enzymes and selected inflammatory markers in postmenopausal women with obesity. The main question it aims to answer is:
Does walking training reduce the risk of liver disease by modulating hepatic-enzymes and selected inflammatory markers? Researchers will compare walking training intervention (designed to the experimental group) to non-training intervention (designed to the control group) to see if the training program works to improve liver health in obese postmenopausal women.
Participants in the experimental (training) group will: underwent a moderate intensity intermittent walking training (MIWT) at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session.
Participants in control group will : not perform any physical training and maintain their usual daily activities.
详细描述
Postmenopausal obesity is an important public health problem accompanied by increased systemic inflammation that escalates the risk of liver disease. Exercise improved inflammatory and hepatic function. Moderate-intensity intermittent-walking-training (MIWT) is the most feasible for obese-postmenopausal-women. This study aimed to investigate whether MIWT could reduce the risk by modulating hepatic-enzymes and selected inflammatory markers. Thirty-six sedentary obese postmenopausal women (mean age 55.7±3.5) were randomly divided into two groups: training group (TG, n=18) and control group (CG, n=18). The TG underwent a MIWT at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session. Body composition, hepatic (alanine-transaminase (ALT), aspartate-transaminase (AST), alkaline-phosphatase, gamma-glutamyl-transferase (GGT) and serum-bilirubin] and inflammatory markers [C-reactive-protein (CRP), and erythrocyte-sedimentation-rate (ESR)) were evaluated at baseline and after 10-week of protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women included are:
- •Postmenopausal (≥1 year of amenorrhea).
- •Obese (body mass index (BMI) ≥30 kg/m2).
- •Sedentary (<120 min/week of low to moderate intensity physical activity at during the past 6 months).
- •Aged 50 to 60 years.
排除标准
- •Suffering from any cardiovascular/renal/pulmonary/metabolic disease.
- •Being under menopausal hormone therapy.
- •Presenting any orthopedic limitations interfering the ability to perform the study intervention.
研究组 & 干预措施
Training group
The training group underwent a moderate intensity intermittent walking training at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session for a period of 10 weeks.
干预措施: Walking training intervention (Behavioral)
Control group
No training intervention was intended for this group.
结局指标
主要结局
Alanine transaminase
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
Serum concentrations of alanine-transaminase (ALT) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Aspartate transaminase
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
Serum concentrations of aspartate-transaminase (AST),are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Alkaline phosphatase
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
Serum concentrations of alkaline-phosphatase are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Gamma glutamyl transferase
时间窗: At baseline and at week 11(after the ten weeks of the training intervention)
Serum concentrations of gamma-glutamyl-transferase (GGT),are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Serum bilirubin
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
Serum concentrations of bilirubin are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
C reactive protein
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
Serum concentration of C-reactive-protein (CRP) are measured from a blood sample (5 ml).
Erythrocyte sedimentation rate
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
Erythrocyte-sedimentation-rate (ESR) are measured from a blood sample (5 ml).
次要结局
- Body composition(At baseline and after ten weeks of the training intervention.)
- Aerobic capacity(At baseline and after ten weeks of the training intervention.)
研究者
Wissal Abassi
Principal Investigator
High Institute of Sports and Physical Education of Kef