Effect of Carnitine Supplementation and Resistance Training on Bone Mineral Density
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Bone Mineral Density measured by dual-energy X-ray absorptiometry (DXA)
研究概览
简要总结
The primary aim of the current research project is to explore whether carnitine supplementation and resistance training may prevent decrements in bone mineral density of aged women.
A secondary aim of this project is to investigate the effect of supplementation on body composition and blood markers.
详细描述
The study includes postmenopausal women. The subjects participate in resistance training (twice a week) for each session consisted of 6 exercises: horizontal seated leg press, seated chest press, leg extension, shoulder press, lat pull-down seated row, seated cable row.
During the 24-weeks training programme participants are supplemented by carnitine with leucine, or leucine alone (placebo).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •postmenopausal
- •lack of restrictions to perform resistance exercises
排除标准
- •cardiovascular disease
- •liver disease
- •kidney disease
- •neuromuscular disease
- •gastrointestinal disorders (including stomach ulcers and erosions)
- •other severe chronic diseases
结局指标
主要结局
Bone Mineral Density measured by dual-energy X-ray absorptiometry (DXA)
时间窗: 24 weeks
Bone mineral density (BMD) of the femoral neck, lumbar vertebrae L1-L4, and total hip determined by Lunar Prodigy Advance DXA (GE, Healthcare, Madison, Wisconsin, USA).
次要结局
- Body Composition: Body Fat Mass, Fat Free Mass, and Skeletal Muscle Mass using a bioelectrical impedance analyzer (InBody720).(24 weeks)
- The circulating markers modification(24 weeks)
研究者
Robert Olek
Principal Investigator
Poznan University of Physical Education