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临床试验/NCT01537627
NCT01537627Unknown不适用

Effects of a Long-term Physical Training Program on Pulmonary and Systemic Aspects in Patients With Chronic Obstructive Pulmonary Disease

Universidade Estadual de Londrina1 个研究点 分布在 1 个国家目标入组 82 人开始时间: 2009年11月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
入组人数
82
试验地点
1
主要终点
Physical activity in daily life

研究概览

简要总结

Several impairing factors contribute to physical limitation in chronic obstructive pulmonary disease (COPD) as deconditioning, muscle dysfunction and physical inactivity. The available literature clearly indicates that these therapeutic targets benefit from exercise training in patients with COPD and, currently, the key point is not whether patients should or not exercise, but which is the specific contribution of each exercise modality to this population. About this topic, the characteristics of a physical training program to be offered to patients have been a point discussed among researchers in this field, although recently the high-intensity training has been recognized as superior in comparison to the low-intensity training. Literature also indicates that, in order to change the sedentary lifestyle of patients with COPD, long-term training programs are indicated. However, a doubt still remains: if long-term programs are one of the key points to reduce physical inactivity, it is not yet clear whether it is necessary to include high-intensity exercises in that long-term program. If the duration is the only factor influencing the outcomes of the program, thus the intensity of training could be reduced, increasing the adherence of patients to the protocol. Based on this hypothesis, the aim of this study is to compare the effects of two physical training protocols in a long-term rehabilitation program (6 months) in patients with COPD: a high-intensity protocol (based on endurance and resistive training) and a low-intensity protocol (based on callisthenic and breathing exercises training). It is expected that the results of this study contribute to the scientific literature by demonstrating whether low- and high-intensity training contribute equally to change the sedentary lifestyle of patients after a long-term exercise program.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
40 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Chronic obstructive pulmonary disease (COPD) diagnosis according to Global Initiative for Chronic Obstructive Lung Disease(GOLD)criteria
  • Clinical stability (i.e. absence of acute exacerbation in the last 3 months)
  • Absence of any unstable/severe cardiac,osteoarticular or neuromuscular disorders which could limit physical activities in daily life
  • Non participation in pulmonary rehabilitation in the last year

排除标准

  • Being unable to attend the outpatient clinic three times per week
  • Inability to understand or cooperate with the assessment methods

研究组 & 干预措施

Low-intensity training (LT)

Active Comparator

干预措施: Physical training (Other)

High-intensity training (HT)

Active Comparator

干预措施: Physical training (Other)

结局指标

主要结局

Physical activity in daily life

时间窗: Up to 4 years

Main variable: time spent in physical activities of at least moderate intensity (min/day)

次要结局

  • Dyspnea sensation(Up to 4 years)
  • Functional exercise capacity(Up to 4 years)
  • Maximal exercise capacity(Up to 4 years)
  • Peripheral muscle force(Up to 4 years)
  • Respiratory muscle force(Up to 4 years)
  • Body composition(Up to 4 years)
  • Health-related quality of life(Up to 4 years)
  • Functional status(Up to 4 years)
  • Lung function(Up to 4 years)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Fabio Pitta, PhD

PhD

Universidade Estadual de Londrina

研究点 (1)

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