跳至主要内容
临床试验/NCT04880421
NCT04880421已完成不适用

Diagnostic Performance of Arterial Time for CT Assessment of Parietal Enhancement Defect for the Diagnosis of Ischemia in Mechanical Small Bowel Occlusions: a Comparative Study With Portal Time

Fondation Hôpital Saint-Joseph1 个研究点 分布在 1 个国家目标入组 158 人开始时间: 2021年4月27日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
158
试验地点
1
主要终点
Diagnostic performance of arterial versus portal phase in CT for the evaluation of parietal enhancement defect

研究概览

简要总结

Intestinal obstruction is a frequent cause of emergency room visits and represents about 4-7% of the causes of acute abdominal pain syndrome and up to 30% in adults over 60 years old.

Although 65 to 80% of patients are treated medically, small bowel obstruction remains a serious pathology, with a high mortality rate that can reach 25% in case of small bowel ischemia. It is necessary to systematically perform a CT scan in the initial workup of small bowel obstructions to confirm the diagnosis, identify the mechanism and detect signs of ischemia that would require emergency surgery.

The best sign for the diagnosis of ischemia is the defect or asymmetry of parietal enhancement of the dilated small bowel. In the literature, this sign is described almost exclusively at portal time. In case of suspicion of mesenteric ischemia (another serious pathology affecting the small bowel), it is recommended to perform an examination with three acquisitions (without injection, arterial time, and portal time).

The department's experience has shown that arterial time is sometimes more sensitive than portal time for visualizing a parietal enhancement defect of the small bowel in mechanical occlusions.

Very few studies have investigated the diagnostic performance of parietal enhancement asymmetry on arterial time in mechanical occlusions of the small bowel.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patient whose age is ≥ 18 years
  • Patient with a diagnosis of mechanical small bowel obstruction on CT performed between April 2014 and December 2019
  • Patient who had a CT scan with at least 3 phases: injection-free, arterial time, portal time
  • French-speaking patient

排除标准

  • Patient who did not have surgery within the first 24 hours
  • Patient with a history of abdomino-pelvic surgery in the month preceding the scan
  • Patient under guardianship or curatorship
  • Patient deprived of liberty
  • Patient under court protection
  • Patient who objects to the use of his or her data for this research

结局指标

主要结局

Diagnostic performance of arterial versus portal phase in CT for the evaluation of parietal enhancement defect

时间窗: Year 1

This ouctome corresponds to the evaluation of the sensitivity, specificity, positive predictive value and negative predictive value of the acquisition for parietal enhancement defect as a sign of ischemia.

次要结局

  • Inter-observer reproducibility of parietal enhancement defect analysis at arterial time(Year 1)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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