Comparison of the Effect of the Preoperative Use of Chlorhexidine, Essential Oil, and Cetylpyridinium Chloride Mouthwashes on Bacterial Contamination During Dental Implant Placement: A Randomized Controlled Clinical Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Oral Rinse Comparison
研究概览
简要总结
The primary aim of this study is to evaluate and compare the efficacy of a 60 second rinse with chlorhexidine, essential oil-based mouthwash, cetylpyridinium chloride mouthwash, or saline solution on bacterial contamination in the buccal vestibule when used preoperatively using the real-time Polymerase Chain Reaction (qPCR).
We hypothesize that preoperative rinse with chlorhexidine mouthwash will result in greater reduction of bacterial counts than with essential oil-based, cetylpyridinium chloride, or saline mouthwashes.
The secondary aim of this study is to evaluate the effect of the tested mouthwashes in reducing the bacterial counts over time.
We hypothesize that preoperative rinse with chlorhexidine mouthwash will result in a reduction of bacterial counts for longer duration than with essential oil-based, cetylpyridinium chloride, or saline mouthwashes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient who is treatment planned for dental implant placement and qualifies for dental implant placement according to the standards of care in the Department of Periodontology at Tufts University School of Dental Medicine.
- •Aged 18 years and above.
- •Partially edentulous.
排除标准
- •Antibiotic therapy within 2 weeks of the study.
- •Active infection in the oral cavity.
- •Known allergy to any of the agents used in the study.
- •Self-reported pregnancy (as the surgical procedure of dental implant placement is elective and typically deferred until after the delivery).
- •Fully edentulous.
- •Patient with severe periodontitis (Clinical attachment loss of 5mm or more in the majority of intraoral sites).
- •Regular use of mouthwashes (once/day).
研究组 & 干预措施
0.12% Chlorhexidine
Alcohol-free Chlorhexidine Gluconate Oral Rinse USP, 0.12% from GUM®
干预措施: Mouthwash (Other)
Essential oil
LISTERINE® ZERO™ Mouthwash
干预措施: Mouthwash (Other)
0.07% Cetylpyridinium Chloride
Crest Pro-Health Multi-Protection Rinse - Refreshing Clean Mint (Procter and Gamble)
干预措施: Mouthwash (Other)
Saline
干预措施: Mouthwash (Other)
结局指标
主要结局
Oral Rinse Comparison
时间窗: 60 seconds rinse
The primary aim of this study is to evaluate and compare the efficacy of a 60 second rinse with chlorhexidine, essential oil-based mouthwash, cetylpyridinium chloride mouthwash, or saline solution on bacterial contamination in the buccal vestibule when used preoperatively using the real-time Polymerase Chain Reaction (qPCR).
次要结局
- Bacterial Count Reduction(60 seconds rinse)