Comparative evaluation of clinical andradiographic effects of ascorbic acidaugmented platelet rich fibrin versus plateletrich fibrin alone in the treatment of Grade IIfurcation involvement: A randomisedcontrolled study.

Periodontitis is aninflammatory destructive disorder of the periodontal supporting structures,which is associated with microbial dysbiosis. Its primary features include theloss of periodontal tissue support , manifested through clinical  attachmentloss , presence of periodontal pocket and radiographically alveolar  boneloss. The goal  of  regenerative periodontal therapy, is to restorethe tooth supporting apparatus that has benn lost due to periodontal disease orinjury . PRF is classified as a second generation platelet concentrate, as itis prepared as a natural concentrate without the addition of anyanticoagulants. Platelet rich fibrin  is an easily prepared , autologousnatural scaffold  harbouring a multitude of growth /differentiationfactor. Vitamin C may lower the risk of periodontal diseases and evenfacilitate  healing  of the periodontium due to its strongantioxidant capacity that allows it to inactivate ROS that  damagestructure and function of tissues.Surgical procedure is done after presurgicaltreatment ,that is scaling and root planning. After oral prophylaxis is done ,1 week follow up is done . After 1 week clinical parameters to be evaluated andsurgery is performed in which OFD  with PRF  is done on one side andon the other side OFD  alongwith  ascorbic acid and PRF is injectedon other side. Then flaps are approximated and then sutured . After thatclinical and radiographic parameters are evaluated at 3 months and 6 months.