Investigation of Effectiveness of Therapeutic Exercises on Target Joint Functions and Gait in Hemophilic Arthropathic Patients.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Haemophilia Joint Health Score
研究概览
简要总结
Arthropathy characterized by synovitis, cartilage degeneration, subchondral and interosseous cysts occur due to hemorrhage in hemophilia. This situation causes to chronic pain, decreasing in range of motion, muscle strength, proprioception. Disorders in these parameters are the main causes of gait dysfunction. The aim of this study is to investigate the effects of therapeutic exercises on target joint functions and gait kinematics, and to determine possible complications related to exercise in hemophilic patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •To be diagnosed as Hemophilia A or Hemophilia B
- •To be over 18 years old
- •To have hemophilic arthropathy in at least one joint
- •Undergoing prophylaxis or factor VIII-IX replacement therapy
排除标准
- •Having another congenital coagulopathy, such as Von Willebrand syndrome
- •To be unable to walk due to hemophilic arthropathy
- •Having another musculoskeletal problem
- •Individuals with inhibitors against Factor VIII-IX
结局指标
主要结局
Haemophilia Joint Health Score
时间窗: Baseline, Change from baseline HJHS at 2 months, Change from baseline HJHS at 6 months
Haemophilia Joint Health Score (HJHS) will be applied to evaluate the joint functions of hemophilic individuals. HJHS is a sensitive and valid test used to determine the severity of clinical symptoms that result from hemarthrosis. This comprises an assessment of joints with regards to swelling, muscle atrophy, crepitus, range of motion, joint pain, strength, and global gait. The score for each joint is summed to obtain a total score ranging from 0 to 124, where no joint damage is indicated by a score of 0.
Range of Motion Analysis with Kinovea Software
时间窗: Baseline, Change from baseline range of motion during gait at 2 months, Change from baseline range of motion during gait at 6 months.
Range of motion (ROM) analysis during gait will be done by analyzing video images with computer software "Kinovea". Kinovea is a free software used by sports and healthcare professionals to analyze video images during physical activity. Furthermore, it is a sensitive method that can be used to evaluate the range of motion of the lower limb joints during gait. ROM analysis of the ankle and knee joints will be done with Kinovea in the heel strike-midstance-toe off and mid-swing phases.
次要结局
- Haemophilia Quality of Life Questionnaire for Adults(Baseline, Change from baseline 6min-WT at 2 months, Change from baseline Quality of life at 6 months)
- Six Minutes Walking Test(Baseline, Change from baseline 6min-WT at 2 months, Change from baseline 6min-WT at 6 months)
研究者
Volkan Deniz, PT
Director
Cukurova University