NCT07585331已完成不适用
Towards Effective, Patient-tailored Anti-plasma Cell Therapies in AL Amyloidosis: Predicting Drug Response and Overcoming Drug Resistance
Fondazione IRCCS Policlinico San Matteo di Pavia1 个研究点 分布在 1 个国家目标入组 250 人开始时间: 2022年1月13日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 250
- 试验地点
- 1
研究概览
简要总结
Through an observational clinical study, partly prospective and partly retrospective, based on the collection of clinical data and on in vitro experimental analyses carried out on residual biological samples obtained during routine clinical procedures, it is proposed to identify predictive biomarkers of in vivo response to first-line therapies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Biopsy-proven systemic AL amyloidosis
- •No IgM clone
- •No history of anti-plasma cell therapy
- •Diagnostic bone marrow aspiration at ARTC
- •Age > 18 years
- •Willingness to allow use of clinical data and diagnostic leftovers of clinical specimens for research purposes through signing a written informed consent.
排除标准
- •Non-AL amyloidosis
- •IgM clone
- •Previous anti-plasma cell therapy
- •Age <18 years
- •Failure to show willingness to allow use of clinical data and diagnostic leftovers of clinical specimens for research purposes.
研究者
Mario Nuvolone
Principal Investigator
Fondazione IRCCS Policlinico San Matteo di Pavia
研究点 (1)
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