NL-OMON52739招募中不适用
The search for biomarkers to enable detection and monitoring of disease progression from NAFLD to NASH and NASH itself; Amsterdam NASH cohort - Amsterdam NASH cohort (ANCHOR) study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Diagnosis of steatosis hepatis on ultrasound or by biopsy or on Fibroscan
- •with CAP >280dB/m
- •>18 years of age
- •ASAT and/or ALAT levels above upper limit of normal in six months prior to
- •BMI >25 kg/m2
排除标准
- •Abusive alcohol use (>20 IU/week)
- •Hepatitis B and/or C
- •Auto-immune hepatitis
- •Wilsons disease/ alpha-1-antitripsine deficiency
- •Haemachromatose
- •Bleeding disorder, including the use of anticoagulant therapy and platelet
- •aggregation inhibitors. Except for subjects using platelet aggregation
- •inhibition monotherapy for the prevention of cardiovascular disease and without
- •a history of any coronary events. In this case the platelet aggregation
- •inhibitor will be discontinued for 7 days before the liver biopsy is performed.
- •Use of drugs with a potential role in aggravation of pre-existing NAFLD
- •Not able or willing to undergo MRI (for example claustrophobia, ICD,
- •pacemaker).
- •Diagnosis of liver cirrhosis and/or hepatocellular carcinoma.
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