The Anabolic Effects of Estrogen on Skeletal Muscles
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 2
- 主要终点
- Muscle hypertrophy
研究概览
简要总结
Purpose: to study the effect of estrogen replacement on muscle hypertrophy in response to 12 weeks resistance training in postmenopausal women Hypothesis: Transdermal administration of 17-β estradiol enhance the anabolic effect of resistance training on muscle mass, strength in postmenopausal women Primary outcome: Muscle hypertrophy (muscle CSA, muscle fiber type specific CSA) Secondary outcome: Messenger RiboNucleic Acid (mRNA)(real-time PCR), protein (western blotting), satellite cell proliferation and activation, Strength, functional test, muscle protein synthese.
Design: Two groups of healthy postmenopausal women (½-5 years after menopause) who have not performed regular resistance exercise (<1 times per week) the last two years. Randomized, controlled intervention study +/- transdermal administration of estrogen (17-β estradiol). Both groups perform 12 weeks of supervised progressive resistance training (3/week) aiming to induce muscle hypertrophy in the legs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Postmenopausal women, more than 6 months, but less than 5 years since last menstruation.
排除标准
- •Less than 2 hours exercise with moderate to high intensity per week the last year, no regular resistance exercise the last 2 years (less than 5 exercise bouts during the last year)
- •No previous or present lower limb injuries which may hinder participation in strength training
- •No use of medicine which may influence the adaptation to strength training such as regular use of nonsteroidal anti-inflammatory drugs and use of statins, no muscle
- •Joint or metabolic diseases or other chronic diseases that would affect the results of the investigation, high blood pressure (>140/90), smoking
研究组 & 干预措施
Exercise + Estrogen
Strength training 3 times a week for 12 weeks. Estrogen patches which provide 100 um pr. 24 hours.
干预措施: Exercise + Estrogen (Other)
Exercise + Placebo
Strength training 3 times a week for 12 weeks. Placebo patches.
干预措施: Exercise + Placebo (Other)
结局指标
主要结局
Muscle hypertrophy
时间窗: 12 weeks
muscle cross sectional area measured by Magnetic resonance imaging (MR) -scans
次要结局
- Fat mass(12 weeks)
- Fat free mass(12 weeks)
- Muscle fiber hypertrophy(12 weeks)
- tendon size(12 weeks)
- Muscle strength(12 weeks)
- Fat cell size(12 weeks)