A Pilot Study on the Influence of Temporo-occipital Transcranial Magnetic Brain Stimulation on Aversive Episodic Memory Performance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- memory recall performance
研究概览
简要总结
A pilot study, examining the effect of repeated transcranial magnetic brain stimulation (rTMS) on the formation of memories with negative valence. The investigators hypothesize that an effective rTMS protocol to reduce memory performance for adverse events can be found.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female
- •Generally healthy
- •Normotensive (BP 90/60mmHg - 140/90mmHg)
- •BMI: 19 - 30 kg/m2
- •Age: 18 - 30 years
- •Fluent German-speaking
排除标准
- •Metal in the brain, skull or elsewhere in the body (e.g., splinters, fragments, clips, etc.)
- •Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS)
- •Cardiac pacemaker or intracardiac lines
- •Medication infusion device
- •Nonremovable Piercings in the head area, pivot teeth (retainers are no exclusion criterion)
- •Tattoos (head area) less than 3 months old or older than 20 years
- •Condition after neurosurgery
- •Hearing problems or tinnitus
- •Not able to sit still due to tremor, tics, itching
- •History of repeated syncope
- •Head trauma diagnosed as concussion or associated with loss of consciousness
- •diagnosis of epilepsy, or a convulsion or a seizure in the past of the participant or his/her close family
- •TMS in the past showing problems
- •Surgical procedures to spinal cord
- •Spinal or ventricular derivations
- •Alcohol or drug intake 48 hours before start of visits
- •Regular intake of any medication or CNS-active medication 48h before visit
- •rMT above the limits of rTMS device.
研究组 & 干预措施
cTBS 50 Hz experiment
Active brain stimulation on the temporo-occipital cortex using the cTBS 50 Hz protocol.
干预措施: rTMS (cTBS 50Hz experiment) (Device)
cTBS sham
Sham brain stimulation on the temporo-occipital cortex using the cTBS 50Hz protocol pattern
干预措施: rTMS (cTBS sham) (Device)
cTBS 50Hz active control
Active brain stimulation on the right superior frontal cortex using the cTBS 50 Hz protocol
干预措施: rTMS (cTBS 50 Hz active control) (Device)
High frequency
Active brain stimulation on the temporo-occipital cortex using the 20Hz protocol
干预措施: rTMS (high frequency) (Device)
Low frequency
Active brain stimulation on the temporo-occipital cortex using the 1Hz protocol
干预措施: rTMS (low frequency) (Device)
cTBS 30Hz
Active brain stimulation on the temporo-occipital cortex using the cTBS 30 Hz protocol.
干预措施: rTMS (cTBS 30 Hz) (Device)
cTBS 30 Hz Active control
Active brain stimulation on the right superior frontal cortex using the cTBS 30 Hz protocol
干预措施: rTMS ( cTBS 30 Hz active control) (Device)
High frequency Active control
Active brain stimulation on the right superior frontal cortex using the 20 Hz online protocol
干预措施: rTMS (high frequency active control) (Device)
Low frequency Active control
Active brain stimulation on the right superior frontal cortex using the 1 Hz offline protocol
干预措施: rTMS (low frequency active control ) (Device)
High frequency sham
Brain stimulation on the dominant temporo-occipital cortex using 10% maximum system output (MSO) and 20 Hz online protocol.
干预措施: rTMS (high frequency sham) (Device)
结局指标
主要结局
memory recall performance
时间窗: On average 1 hour after intervention
The difference between valence specific (negative, positive, and neutral) memory performance as assessed by a standard picture recall episodic memory task.
次要结局
- Working memory performance(On average 1 hour after intervention)
研究者
Prof. Dominique de Quervain, MD
Director Division of Cognitive Neuroscience
University of Basel