Damage and Renal Clearance of Glycocalyx in Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Aortic clamping time
研究概览
简要总结
The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory.
The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Over 18 years of age
- •Patients who underwent cardiac surgery for a single valve change or replacement
排除标准
- •Stage 3 renal failure patients
- •Patients with a previous diagnosis of hematological malignancy
- •Patients undergoing pulmonary valve change surgery.
- •Patients undergoing Bentall and Bono surgery.
- •Patients Undergoing Coronary Artery Bypass Surgery
结局指标
主要结局
Aortic clamping time
时间窗: 2 hours
Duration of aortic clamping time in minutes
Hyaluronic acid levels in urine before surgery
时间窗: 30 minutes
Quantity of hyaluronic acid in urine before surgery
Hyaluronic acid levels in blood before surgery
时间窗: 30 minutes
Quantity of hyaluronic acid in blood before surgery
Hyaluronic acid levels in urine after surgery
时间窗: 30 minutes
Quantity of hyaluronic acid in urine before surgery
Extracorporeal circulation time
时间窗: 2 hours
Duration of Extracorporeal Circulation in minutes
Sydecan -1 levels in urine before surgery
时间窗: 30 minutes
Quantity of Sydecan -1 in urine before surgery
Hyaluronic acid levels in blood after surgery
时间窗: 30 minutes
Quantity of hyaluronic acid in blood after surgery
Sydecan -1 levels in blood before surgery
时间窗: 30 minutes
Quantity of Sydecan -1 in blood before surgery
Sydecan -1 levels in blood after surgery
时间窗: 30 minutes
Quantity of Sydecan -1 in blood after surgery
Sydecan -1 levels in urine after surgery
时间窗: 30 minutes
Quantity of Sydecan -1 in urine after surgery
次要结局
未报告次要终点
研究者
Miguel Ayala León
cardiovascular critical care unit director
Hospital Beneficencia Espanola de Puebla