Modulation of Motor Cortex Excitability by Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Changes in Motor-evoked Potentials Ratios
研究概览
简要总结
Investigating modulation of motor cortex excitability by transcranial magnetic stimulation and transcranial direct current stimulation.
详细描述
Purpose of this pilot study is to modulate the motor cortex excitability by transcranial magnetic stimulation and transcranial direct current stimulation. Electromyography will be recorded on right abductor digiti minimi muscle to find the motor threshold and measure motor evoked potentials for each healthy participant. In addition, electroencephalography (EEG) data will be collected on the scalp with a high-density EEG net. Eighteen healthy participants will be in this study. Each participant will be seated in a reclining chair and applied non-invasive magnetic and electrical stimulations on the scalp. At baseline, the participant's resting motor threshold (RMT) will be estimated by adjusting the intensity of TMS applied on the left motor cortex to achieve motor-evoked potentials of about 50 uV with 10 TMS pulses at a rate of 0.25 Hz. Then a 3-condition, 3-session, 6-sequence randomized crossover experiment will be used to characterize and compare three versions of tDCS stimulation: anode, cathode, sham. Before and after a 10-min tDCS condition is applied, TMS pulses at 120% of RMT intensity will be applied for 10 minutes and TMS-evoked potential and motor-evoked potential amplitudes will be measured. Each session has at least 1-day gap to remove outlasting effects. We will also be collecting structural magnetic resonance imaging (sMRI) to target primary motor cortex precisely.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
This is a double-blind and cross-over study.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Between the ages of 18 and 35
- •Right-handed
- •Capacity to understand all relevant risks and potential benefits of the study (informed consent)
- •Willing to comply with all study procedures and be available for the duration of the study
- •Speak and understand English
排除标准
- •Prior concussion
- •Diagnosis of eating disorder (current or within the past 6 months)
- •Diagnosis of obsessive compulsive disorder (lifetime)
- •Attention-deficit/hyperactivity disorder (currently under treatment)
- •Neurological disorders and conditions, including, but not limited to:
- •History of epilepsy
- •Seizures (except childhood febrile seizures and electroconvulsive therapy-induced seizures)
- •History of stroke
- •Parkinson's disease
- •Multiple sclerosis
- •Cerebral aneurysm
- •Brain tumors
- •Medical or neurological illness or treatment for a medical disorder that could interfere with study participation (e.g., unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment)
- •Prior brain surgery
- •Any brain devices/implants, including cochlear implants and aneurysm clips
- •Traumatic brain injury
- •Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
研究组 & 干预措施
anodal tDCS
Two electrodes will be applied to the scalp (one on the left motor cortex, one on the right supraorbital cortex). This anodal tDCS on the left motor cortex will be stimulated with 2mA for 10 minutes.
干预措施: anodal tDCS (Device)
cathodal tDCS
Two electrodes will be applied to the scalp (one on the left motor cortex, one on the right supraorbital cortex). This cathodal tDCS on the left motor cortex will be stimulated with -2mA for 10 minutes.
干预措施: cathodal tDCS (Device)
sham tDCS
Two electrodes will be applied to the scalp (one on the left motor cortex, one on the right supraorbital cortex). Sham stimulation with 2mA for 40 seconds will be applied.
干预措施: sham tDCS (Device)
结局指标
主要结局
Changes in Motor-evoked Potentials Ratios
时间窗: right before and after 2mA tDCS stimulation for 10 minutes at each session
The investigators will record motor-evoked potentials and calculate changes in between before and after 2mA tDCS stimulation for 10 minutes.
Changes in TMS-evoked Potentials Ratios
时间窗: right before and after 2mA tDCS stimulation for 10 minutes at each session
The investigators will record TMS-evoked potentials using EEG and calculate changes in between before and after 2mA tDCS stimulation for 10 minutes.
次要结局
- Changes in Resting-state EEG Dynamics Ratios(4 minutes recordings before and after each 2mA tDCS stimulation for 10 minutes at each session)