Risk of Uncomplicated Peptic Ulcer in the General Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 4,000
- 试验地点
- 1
- 主要终点
- Relative risk (ratio) of uncomplicated peptic ulcer (UPU) associated with low dose ASA, other antiinflammatory drugs and other common drugs for chronic diseases(paracetamol, SSRI, tricyclic antidepressants, anticoagulants, acid suppressing drugs)
研究概览
简要总结
The analyses are conducted in a previous population-based cohort study using The Health Improvement Network database in the UK (Cai et al 2009).The aims of the post hoc analyses are:
To estimate the relative risk of uncomplicated symptomatic peptic ulcer (UPU) associated with use of low dose aspirin (ASA) and other anti-inflammatory drugs (NSAIDs, steroids) in the general population To estimate the dose-response and duration-response associated with use of these drugs To estimate the relative risk of UPU associated with naive/non-naive use of low dose ASA in the general population To evaluate the effect of proton pump inhibitors (PPI) (alone or in combination with anti-inflammatory drugs) on the occurrence of UPU in the general population To investigate the management of low dose ASA/oral antiplatelets after UPU
详细描述
Risk of uncomplicated peptic ulcer in the general population
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 40 Years 至 84 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 40-84 years in 1997-2005 ( see study population description)
排除标准
- •Patients aged below age 40 and 85 years and above ( see study population description)
研究组 & 干预措施
Cases
Patients with symptomatic peptic ulcer (UPU)
干预措施: Risk of symptomatic peptic ulcer (Drug)
Control group
Control group without symptomatic peptic ulcer (UPU).
干预措施: Risk of symptomatic peptic ulcer (Drug)
结局指标
主要结局
Relative risk (ratio) of uncomplicated peptic ulcer (UPU) associated with low dose ASA, other antiinflammatory drugs and other common drugs for chronic diseases(paracetamol, SSRI, tricyclic antidepressants, anticoagulants, acid suppressing drugs)
时间窗: From Januar 1 1997 till December 31 2005, an expected average of 4 years.
Relative risk (ratio) of UPU associated with current use of the different types of drugs versus non-use.
Management of aspirin after uncomplicated peptic ulcer (UPU).
时间窗: From January 1, 1997 till december 31, 2005, an average of 4 years
次要结局
未报告次要终点