TS HYPE - Turner syndrome and Hypertension; a double-blinded randomised interventional trial.

Organisation name was not entered0 个研究点目标入组 120 人开始时间: 2009年2月25日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•1.TS as verified through chromosomal genotyping.
•2.Age > 18 years.
•3.Hypertension defined as: a) 24-hour ambulatory blood pressure with 24-hour blood pressure > 118/75 mmHg, daytime values > 125/80 mmHg, and/or: night-time values > 102/66 mmHg 28, 29. b) Hypertension as documented with earlier clinical or ambulatory hypertension by a medical doctor with subsequent commencement anti-hypertensive medications.
•4.Expected stationary status of either ongoing or absent oral oestrogen substitution therapy (HRT).
•5.Informed consent – in writing and orally, as well as written authority.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•1. Contraindication to performing MR scans:
•a)Claustrophobia,
•b)Magnetic or electric foreign bodies – including; cardiac pacemakers, magnetic cerebrovascular clips and electric non-removable appliances dosing medicine and/or:
•c)Extreme adiposity (BMI > 35 kg/m2).
•2. Contraindication to BB therapy
•a)Allergy to the ingredients,
•b)Significant bradycardia or advanced atrioventricular block,
•c)Decompensated heart failure and/or:
•d)Asthma bronchiale.
•3. Contraindications to ARB therapy:
•a)Allergy to the ingredients,
•b)Pregnancy, and/or:
•c)Known renal artery stenosis, severe renal insufficiency.
•d)Severe hepatic failure, biliary cirrhosis and cholestasis
•4. Mechanical aortic valve or aortic prosthesis
•5. Former or present malignant disease.
•6. Diagnosed chronic liver disease (hepatitis or cirrhosis), as elevated liver enzymes are a common finding regarded as non-specific.
•7. Other severe acute or chronic disease of known or presumed influence on the parameters of the study.

发起方

Organisation name was not entered