Investigating Digestive Properties of Carbohydrate-based Foods
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Glycemic response
研究概览
简要总结
Gastric emptying rate, glycemic response, fermentation, and appetitive response are being assessed after consumption of traditional West African carbohydrate-based foods (pearl millet couscous, pearl millet thick porridge) and Western type carbohydrate-based foods (wheat couscous, white rice).
详细描述
Anecdotal evidence suggests that couscous made from pearl millet (Pennisetum glaucum), hereby referred to as millet couscous, is highly satiating in populations living in the West African Sahel. Results from a previous human study conducted the investigators indicated that traditional West African foods made from pearl millet and sorghum (millet couscous, millet thick porridge, and sorghum thick porridge) exhibit markedly delayed rates of gastric emptying compared to Western foods (pasta, boiled potatoes, and white rice) in a population from Mali, Africa. The delayed gastric emptying rate of the thick porridges can be attributed at least partially to the impact of viscosity, while the cause of the delayed gastric emptying rate of the millet couscous remains unclear. The overall aim of this research is to determine why millet couscous exhibits a delayed rate of gastric emptying, while also assessing other digestive properties to gain a better understanding of the factors that could be contributing to this outcome. Therefore, gastric emptying rate, glycemic response, fermentation, and appetitive response are all being assessed for West African and Western foods in a population residing in the United States.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal body mass index (18.5 < BMI < 25 kg/m2)
- •Normal fasting blood glucose
排除标准
- •Allergy to millet
- •Allergy or sensitivity/intolerance to gluten
- •History of gastrointestinal disease
- •Pregnant or nursing
研究组 & 干预措施
Pearl millet couscous - made in Senegal
Steamed pearl millet couscous - commercially produced in Senegal
干预措施: Pearl millet couscous - made in Senegal (Other)
Pearl millet couscous - made in USA
Steamed pearl millet couscous - pearl millet obtained from Senegal but processed and prepared in USA
干预措施: Pearl millet couscous - made in USA (Other)
Pearl millet thick porridge
Thick porridge prepared according to traditional West African methods with pearl millet obtained from Senegal but processed and prepared in USA
干预措施: Pearl millet thick porridge (Other)
Wheat couscous
Steamed wheat couscous - wheat flour processed and prepared in USA
干预措施: Wheat couscous (Other)
White rice
White rice - medium-grain prepared using a rice cooker
干预措施: White rice (Other)
结局指标
主要结局
Glycemic response
时间窗: Acute study; 4 hours of measurement after consumption of test food
Blood glucose is being measured using continuous glucose monitors.
Gastric emptying rate
时间窗: Acute study; 4 hours of measurement after consumption of test food
Breath test is being performed using 13C-octanoic acid mixed into test meals.
次要结局
- Breath hydrogen (fermentability)(Acute study; 4 hours of measurement after consumption of test food)
- Appetitive response(Acute study; 4 hours of measurement after consumption of test food)
研究者
Bruce R. Hamaker
Distinguished Professor of Food Science
Purdue University
