Priming Dose of Rocuronium and Milliamperage Value for Supramaximal Stimulation of NeuroMuscular Transmission Monitor
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Supramaximal stimulation value
研究概览
简要总结
To shorten induction time, some anesthesiologist gives a priming dose of muscle relaxant before starting Neuromuscular Transmission monitor (NMT). To properly evaluate neuromuscular function during the surgury, baseline supramaximal stimulation of the monitored nerve is mandatory. Not knowing if the priming dose of muscle relaxant affects the supramaximal stimulation current setting, The investigators designed this study to find out.
详细描述
The NMT monitor module automatically determines the current needed for the supramaximal stimulus, and maintains this current throughout the procedure.
The supramaximal current is the current above which there is no increase in the evoked muscle response. At this stimulus current, all motor units are firing in response to nerve stimulation. According to previous studies, the current was significantly increased in the presence of edema and peripheral neuropathy. In this study, the route of administration, dosage, dosage regimen, and treatment period are basically the same as the investigators anesthesia department's routine procedure for general anesthesia. The difference will be the time the investigators set between the priming dose to final dose of rocuronium is 2 minutes. The investigators use 2 minutes as the peak effect of rocuronium is 105±36S.
To properly evaluate neuromuscular blockade during the surgery, baseline supramaximal stimulation of the monitored nerve is mandatory. Not knowing if the priming dose of muscle relaxant affects the supramaximal stimulation current setting, the investigators designed this study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients receiving general anesthesia and use rocuronium for induction
排除标准
- •Muscular disease
- •Peripheral neuropathy
- •Difficult airway or difficult mask ventilation
- •Allergy to study related medication
- •Pregnant woman
- •< 20-year-old or > 65-year-old
- •BMI <18.5 or BMI>24.9
结局指标
主要结局
Supramaximal stimulation value
时间窗: since general anesthesia induction to endotracheal tube intubation, about 10 minutes
whether the supramaximal stimulation changs after 2 minutes of priming dose of muscle relaxant use
次要结局
- dose of rocuronium(since general anesthesia induction to endotracheal tube intubation, about 10 minutes)
- supramaximal stimulation value change by time(since general anesthesia induction to endotracheal tube intubation, about 10 minutes)
- Time to intubation(since general anesthesia induction to endotracheal tube intubation, about 10 minutes)
- Intubation condition(since general anesthesia induction to endotracheal tube intubation, about 10 minutes)
研究者
Wei Chieh Lai
Principal investigator
Taipei Medical University Hospital