The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Firing rate changes
研究概览
简要总结
Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders. This project aims to identify the how the choices individuals make influence what, and how, people remember by combining disparate techniques in computational modeling and direct brain recordings in human subjects. The researcher developed a dual-task paradigm, probing how decisions in one task affect immediate recognition memory. To examine the neural mechanisms underlying model-free RL's influence on memory, the researcher will record local field potential (LFP) and single neuron activity in various brain regions as epilepsy patients perform the proposed task. The results of this project will identify specific neurocomputational mechanisms unifying decision-making and memory processes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Has seizure activity which is deemed non-responsive to standard pharmacological intervention(s), as determined by treating Neurologist and established clinical practices
- •Has elected to receive clinically indicated intracranial EEG (electrocorticography (ECoG), stereoelectroencephalography (SEEG)) and/or temporal responsive neurostimulation (RNS) for medication-refractory epilepsy outside of this research study, as determined by treating clinician(s) and per current clinical practice
- •Capacity to provide written informed consent
- •Language proficiency in English or Spanish
- •Willing and able to comply with all study-related procedures
排除标准
- •History of psychosis, such as in the context of depressive or manic episode.
- •Active suicidal ideation with intent, suicide attempt within the last six months, or other serious suicide risk
- •Inability to provide informed consent or reliably participate in study assessments, as per the Montreal Cognitive Assessment (MOCA; score < 26) or in the opinion of the evaluating neuropsychologist.
- •Individuals unwilling or unable to undergo electrode implantation procedures
- •Medical contraindications to neurosurgery or for general anesthesia, neurosurgery, or an MRI scan (required for electrode implantation)
- •Neurological disorder other than epilepsy or other significant brain pathology, if contraindicated in the opinion of implanting neurosurgeon.
- •Women who are pregnant
结局指标
主要结局
Firing rate changes
时间窗: During task participation, approx. 30-45 min in the first 2 weeks of hospital stay
Single-neuron activity recorded from the hippocampus, amygdala, and frontal cortex. Single-neuron activity refers the micro-scale changes in single-neuron action potentials recorded by microelectrodes implanted in subcortical regions. Firing rate changes (measured as difference in spikes/seconds \[Hz\]) will be reported for neurons as a function of how behavior changes when the value of choices is altered.
Local-field potentials changes
时间窗: During task participation, approx. 30-45 min in the first 2 weeks of hospital stay
Detection of local-field potentials (LFPs) in the various regions (hippocampus, amygdala, and frontal cortex). Local field potentials are the biological voltages recorded by macroelectrodes implanted in participant's subcortical regions as part of their treatment for epilepsy. LFP changes (measured as increases or decreases in voltage) as a function of participant behavior will be recorded, and in response to the task manipulation of the value of choices during the decision-making task
次要结局
- Number of hit rates for Memory performance(During task participation, approx. 30-45 min in the first 2 weeks of hospital stay)
- Number of hit rates for decision-making(During task participation, approx. 30-45 min in the first 2 weeks of hospital stay)
- Reaction time(During task participation, approx. 30-45 min in the first 2 weeks of hospital stay)
研究者
Salman Ehtesham Qasim, Ph.D.
Assistant Professor
Rutgers, The State University of New Jersey