Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and lower postoperative complications
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 715
研究概览
简要总结
Kim DJ, Mayo NE, Carli F, Montgomery DL and Zavorsky GS; Responsive Measures to Prehabilitation in Patients undergoing bowel resection surgery. Toboku J. Exp. Med. 2009, 217, 109-115.
Carli F, Charlebois P, Stein B, Feldman L, Zavorsky G, Kim DJ, Scott S, Mayo NE. Randomized clinical trial of prehabilitation in colorectal surgery. BJS 2010; 97: 1187-1197.
JJ Dronkers, H Lamberts, IMMD Reutelingsperger, RH Naber, CM Dronkers-Landman, A Veldman and NLU van Meeteren; Preoperative therapeutic programme for elderly patients scheduled for elective abdominal oncological surgery: a randomized controlled pilot study. Clinical Rehabilitation 2010; 24: 614–622.
GILLIS, C., LI, C., LEE, L., AWASTHI, R., AUGUSTIN, B., GAMSA, A., LIBERMAN, A.S., STEIN, B., CHARLEBOIS, P., FELDMAN, L.S. and CARLI, F., 2014. Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer. Anesthesiology, 121(5), pp. 937-947
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Adult patients undergoing elective colorectal surgery for cancer.
排除标准
- •metastatic disease known preoperatively,
- •paralytic or immobilized patients (not capable to perform exercise or 6MWT),
- •premorbid conditions or orthopedic impairments that contraindicate exercise (to be assessed by sport physician involved in and during cardiopulmonary exercise testing),
- •cognitive disabilities,
- •chronic renal failure (dialysis or creatinine > 250 µmol)m
- •ASA score 4 or higher,
- •illiteracy (disability to read and understand Dutch),
- •planned abdominoperineal resection (inability to perform postoperative tests),
- •second primary tumour other than colorectal carcinoma simultaneously diagnosed,
- •not able to delay surgery for four weeks due to for example clinical signs of obstruction or short-course neoadjuvant radiotherapy, directly followed by surgery.