A Phase IV double blind multi-site, individually randomised parallel group controlled trial investigating the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in patients in primary care who are taking long term maintenance antidepressants but now feel well enough to consider stopping medication. - ANTLER

PRIMENT Clinical Trials Unit, UC0 个研究点目标入组 479 人开始时间: 2017年4月4日最近更新: 2020年7月20日

适应症

试验速览

暂无简介。

•1)have had at least two episodes of depression
•2)be aged 18-74 years (we have excluded older people as different assessments for depression are used in the older age groups)
•3)be taking antidepressants for 9 months or more and currently taking: citalopram 20mg, sertraline 100mg, fluoxetine 20mg or mirtazapine 30mg
•4)Satisfactory Adherence to medication
•5)are considering stopping their antidepressant medication
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 400
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 79

•1)meet internationally agreed (ICD10) criteria for a depressive illness
•2)have bipolar disorder, psychotic illness, dementia, alcohol or substance dependency, or a terminal illness
•3)are not able to complete self-administered questionnaires in English
•4)have contraindications for any of the prescribed medication
•5)pregnancy or intention to get pregnant within the next 12 months
•6) use of monoamine oxidase inhibitors
•7) allergies to placebo excipients
•8) Current enrolment in another CTIMP

发起方

PRIMENT Clinical Trials Unit, UC