Effects of Computer-based Cognitive Training on Gait Function in Individuals With Parkinson Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Gait Function
研究概览
简要总结
Parkinson's Disease (PD) is a neurodegenerative, progressive illness. It is a multi-system disease that influences not only the motor but also the cognitive and autonomic systems. The main cognitive impairment in individuals with PD is found in executive function (EF). EF is defined as a set of cognitive skills necessary for planning, monitoring and executing sequences of complex activities.
The primary study hypothesis is that computer-based training aimed at improving executive function will have a beneficial effect on gait functions.
详细描述
Parkinson Disease (PD) is a neurodegenerative, progressive illness. It is a multi-system disease that influences not only the motor but also the cognitive and autonomic systems. The main cognitive impairment in individuals with PD is found in executive function (EF). EF is defined as a set of cognitive skills necessary for planning, monitoring and executing sequences of complex activities. Previous studies have revealed some relation between cognitive states and physical functions in healthy adults. Few studies have examined the effect of computer-based cognitive training on various populations. These studies showed a positive emotional-cognitive effect in those populations. This type of intervention plan was also applied to PD patients. However, there are no reports on the effect of intentional cognitive training on gait functions. The purpose of the study is to assess whether cognitive training, designed to improve EF ability, can also improve gait function in PD patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Idiopathic PD.
- •Aged 50-80, living in north region of Israel.
- •Receive regular medications for PD.
- •Not suffering from irregular cognitive disturbance or MMSE<
- •Measured 1-3 on the Hoehn & Yahr scale.
- •Have access to a computer and the ability to operate it.
排除标准
- •Brain operation, including DBS transplant.
- •History of orthopedic problems that can impair gait (hip/knee fractures and back problems).
- •Orthopedic operation on lower limbs performed no later than six months prior to the beginning of the study.
- •Unbalanced general health: uncontrolled diabetes or blood pressure, etc.
- •Inability to walk independently.
- •Immunodeficiency diseases, active cancer, ischemic diseases.
- •Vision impairment, partial/full blindness.
- •Having participated in similar research or cognitive assessment during the previous year.
- •Have received cognitive or gait training under physical therapy or other programs.
研究组 & 干预措施
Computerized cognitive training
A 12 week computerized cognitive training
干预措施: Computerized cognitive training (Other)
结局指标
主要结局
Gait Function
时间窗: 18 weeks
At enrollment eligible individuals will undergo a thorough baseline assessment using a predefined set of tests and performance measurements. Within a week after enrollment each individual will receive guided training on the use of the intervention tool, the Attengo™ software program. Thereafter they will train at their homes, at least three times a week, for a period of 12 weeks. Follow up assessments will be performed within a week of the end of the training period and 4 weeks thereafter to check for long-term cognitive and motor changes.
次要结局
- Executive function(18 weeks)
- Quality of life.(18 weeks)
研究者
Uzi Milman
Director, Clinical Research Unit, Clalit Health Services, Haifa and Western Galilee District and the Department of Family Medicine, Faculty of Medicine, Technion- Israel Institute of Technology, HAIFA, ISRAEL.
Clalit Health Services