Cost-Effectiveness of Chlorhexidine Bathing vs. Active Surveillance Cultures to Prevent Acquisition of Methicillin-resistant Staphylococcus Aureus and Other Hospital-Acquired Infections: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,518
- 试验地点
- 1
- 主要终点
- Acquisition of Methicillin-resistant Staph Aureus (MRSA) Colonization or Infection
研究概览
简要总结
This pilot study in our medical intensive care unit will evaluate the clinical and cost-effectiveness of an active surveillance program for methicillin-resistant Staphylococcus aureus (MRSA), compared to routine daily bathing with chlorhexidine gluconate (CHG)-impregnated cloths. Outcomes include rate of MRSA acquisition, and of other hospital-acquired infections (e.g., catheter-associated bloodstream infections).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients admitted to the medical intensive care unit (ICU) are eligible for inclusion
排除标准
- •Patient refusal
- •Contraindication to nasal swabbing (arm 1)
- •Allergy/sensitivity to chlorhexidine gluconate (CHG) (arm 2)
研究组 & 干预措施
1
Active surveillance cultures (ASC) (via nasal swabs) will be performed for all patients admitted to the medical intensive care unit (ICU) during the designated study period. All patients will be placed in contact isolation until nasal swabs return negative; otherwise will remain in isolation.
干预措施: Nasal swabs for MRSA culture (Other)
1
Active surveillance cultures (ASC) (via nasal swabs) will be performed for all patients admitted to the medical intensive care unit (ICU) during the designated study period. All patients will be placed in contact isolation until nasal swabs return negative; otherwise will remain in isolation.
干预措施: Contact isolation (Other)
2
Chlorhexidine gluconate (CHG) cloths will be used to bathe patients daily instead of standard soap and water. Active surveillance cultures (ASC) will also be used in this arm, but results will be blinded and not used to determine whether patients should be in contact isolation.
干预措施: Nasal swabs for MRSA culture (Other)
2
Chlorhexidine gluconate (CHG) cloths will be used to bathe patients daily instead of standard soap and water. Active surveillance cultures (ASC) will also be used in this arm, but results will be blinded and not used to determine whether patients should be in contact isolation.
干预措施: Chlorhexidine gluconate (Drug)
结局指标
主要结局
Acquisition of Methicillin-resistant Staph Aureus (MRSA) Colonization or Infection
时间窗: During ICU stay
Number of patients who acquired MRSA by the time of ICU discharge (based on nasal swab or clinical culture).
次要结局
- Number of Participants With Central Line Associated Bloodstream Infection(During ICU stay up to six months)
- Vancomycin Resistant Enterococcal Infection or Colonization(During ICU stay)