Magnetic Resonance Imaging in Cerebral Small Vessel Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Progression in total cerebral small vessel disease burden
研究概览
简要总结
Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) may represent as a sensitive and robust tool to detect early changes in brain subtle structures and functions. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.
详细描述
Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) is sensitive to change in white matter structure and subtle vascular function alternation which correlates with cognition impairments in cSVD. MRI manifestation may also represent as useful surrogate marker. Development of advanced MRI technologies promotes their invaluable application in brain and vascular qualitative and quantitative assessment. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical evidence of cerebral small vessel disease or MRI evidence of lacunar infarcts and white matter hyperintensity
- •No disability (modified Rankin's scale < 2)
- •No dementia (MMSE > 24 and absence of dependence in daily activities)
- •Able and willing to consent
排除标准
- •Contraindications to MRI
- •Standard MRI of bad quality due to movement artefacts
- •Unable to tolerate MRI
结局指标
主要结局
Progression in total cerebral small vessel disease burden
时间窗: 1 year
Total cSVD burden assessed by MRI
次要结局
- Progression in congnitive impairments(1 years)
- Modified Rankin Scale(90 days and 1 year after qualifying event)
- Recurrent ischemic events(1 year)
研究者
Xin Lou
Department of Radiology
Chinese PLA General Hospital