ACTRN12621001329853招募中2 期
Safety and Efficacy of Preoperative Stereotactic Radiosurgery for Treatment of Brain Metastases: A Phase II Study
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Patients aged 18 years or older.
- •ECOG Performance Status 0, 1 or 2.
- •Life expectancy at least 6 months.
- •Prior histopathological diagnosis of cancer other than small cell lung cancer, lymphoma, and germ cell tumours.
- •MRI of the brain with findings strongly suggestive of metastatic tumour(s) as assessed by the radiologist.
- •MRI evidence of single or multiple BM lesions amenable for SRS as discussed both by Radiation Oncologist and Neurosurgeon.
排除标准
- •Not a surgical candidate per neurosurgeon's discretion.
- •Disseminated intracranial or leptomeningeal disease.
- •Neurologically unstable patients or requiring emergent surgical decompression.
- •Patients with Brain Metastases 5cm or larger.
- •Cytotoxic Chemotherapy within 7 days prior to SRS.
- •Anti-Vascular endothelial growth factor (VEGF) therapy within 6 weeks of SRS (risk of fatal brain haemorrhage with surgical resection).
- •Inability to tolerate SRS (ie, the inability to lie flat in treatment bed).
- •Contraindication for MRI.
研究者
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