NCT05093413已完成不适用
Olfactory Decision-making and Deprived Sleep
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 2
- 主要终点
- Behavior an olfactory perceptual decision-making task
研究概览
简要总结
This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •At least 18 years old
- •Fluent English speakers
排除标准
- •History of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)
- •History of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.)
- •Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)
- •Cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)
- •Use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)
- •Smell or taste dysfunction
- •History of severe allergies requiring hospitalization for treatment
- •History of severe asthma requiring hospitalization for treatment
- •Habitual smoking
- •History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)
- •Dieting or fasting
- •History of sleep disorders (e.g., obstructive sleep apnea, narcolepsy, insomnia, etc.) Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.)
- •Electronic implants (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.)
- •History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers
- •Left-handedness
- •Claustrophobia
结局指标
主要结局
Behavior an olfactory perceptual decision-making task
时间窗: Up to 24 hours after the intervention
Food-like perceptual responses to binary food-nonfood odor mixtures
次要结局
- Resting-state functional magnetic resonance imaging(Up to 24 hours after the intervention)
研究者
Christina Zelano
Principal Investigator
Northwestern University
研究点 (2)
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