Study of the Usefulness of Blood Cells for the Analysis of Metabolic Recovery After Weight Loss (METAHEALTH-TEST)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Body composition
研究概览
简要总结
The aim of this study is to design and validate a test, METAHEALTH-TEST, based in gene expression analysis in blood cells, to quickly and easily analyse metabolic health. This test will be used to analyse metabolic improvement in overweight/obese individuals and in metabolically obese normal-weight (MONW) individuals after undergoing a weight loss intervention and/or an intervention for improvement in eating habits and lifestyle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 18-45 years
- •Participants with no chronic disease (excluding those related to overweight/obesity)
排除标准
- •Minors or older than 45 years
- •Presence of a metabolic illness
- •Intake of regular medication or drugs
- •Precedents of alcohol or drug consumption
- •Physic of psychic disability
结局指标
主要结局
Body composition
时间窗: 6 months (OW-OB and MONW groups)
Body composition (fat mass in kg) measured using a DXA scanner
Number of individuals responding to fasting assessed by changes in gene expression profile of blood cells
时间窗: 6 months (OW-OB and MONW groups)
The effect of fasting on gene expression profile of blood cells will be analyzed by real-time RT-qPCR and microarray
Weight
时间窗: 6 months (OW-OB and MONW groups)
Weight (kg)
Body Mass Index (BMI)
时间窗: 6 months (OW-OB and MONW groups)
Weight and height will be combined to report BMI in kg/m\^2).
Circulating gamma-glutamyl transpeptidase (GGT)
时间窗: 6 months (OW-OB and MONW groups)
GGT measured in U/L
Circulating glucose, triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and C-reactive protein (CRP)
时间窗: 6 months (OW-OB and MONW groups)
Circulating parameters measured in mg/dL
次要结局
- Waist-hip ratio(6 months (OW-OB and MONW groups))
- Blood pressure(6 months (OW-OB and MONW groups))
- Height(6 months (OW-OB and MONW groups))