NCT02247622Unknown不适用
Primary Sclerosing Cholangitis Telomere Length
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Telomere length
研究概览
简要总结
PSC is a chronic cholestatic disorder. The investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.
详细描述
Primary sclerosing cholangitis (PSC) and colitis are chronic inflammatory disorders with malignant potential. Telomerase is an enzyme complex that lengthens telomeres and has enhanced expression in numerous malignancies. In this study, we evaluated the telomerase gene copy number, telomere length, cells in senescence, aneuploidy and additional parameters of telomere dysfunction from peripheral blood lymphocytes of patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •informed consent
- •documented PSC and inflammatory bowel disease
排除标准
- •under 18 years, above 80 y
- •known active malignancy
- •decompensated cirrhosis
- •patients who cannot sign informed consent
结局指标
主要结局
Telomere length
时间窗: 1.5 years
次要结局
- number of cells with increased telomerase RNA component (TERC) expression(1.5 years)
研究者
研究点 (1)
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