Identifying the Neurofunctional Connections Supporting Mindfulness Meditation Based Analgesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Blood oxygenation level dependent (BOLD) signaling
研究概览
简要总结
Mindfulness meditation has been shown to reduce pain in experimental and clinical settings, and the neural mechanisms underlying this analgesia are distinct from that of placebo related beliefs in the utility of the meditation. Although previous studies have identified potential cortical and sub-cortical targets responsible for mediating these effects, the connectional relationships between them remains largely unexplored. The present study will use blood-oxygen-level dependent (BOLD) neuroimaging to assess functional connections supporting mindfulness meditation.
详细描述
Mindfulness meditation, significantly reduces pain in experimental and clinical settings. Although findings from this laboratory provide novel insights into some of the brain mechanisms supporting the modulation of pain by meditation , the specific analgesic mechanisms engaged during mindfulness meditation remain poorly characterized.
To date, there are no studies that have identified the neurofunctional connections supporting mindfulness meditation-based pain relief. Employing fMRI, the objective of this study will be to determine the neural systems of action supporting mindfulness-based pain relief. The study will determine if higher order brain regions are involved in mindfulness-based analgesia. The results from this aim will identify a neural marker(s) for meditation-related pain relief, a critical step in defining how meditation reduces pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Subjects will be randomly assigned to two groups by the research coordinator. Investigators, study staff and MRI technicians will be blind as to the participant's group assignment.
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal volunteers between ages 18 and
- •Men and women of all races will be included
排除标准
- •Subjects with a history of psychiatric or neurological disorders.
- •Subjects will be excluded if they report being claustrophobic.
- •Subjects with a prior history of meditation training will be excluded.
- •Subjects with ferrous metal or electronic devices (e g., pacemakers) implanted in there body will be excluded.
- •Pregnant subjects will be excluded.
- •Subjects that demonstrate no pain to noxious temperatures (>49°C) or excessive responses to temperatures at or below 43°C will be excluded.
结局指标
主要结局
Blood oxygenation level dependent (BOLD) signaling
时间窗: Up to 3 weeks
Changes in blood oxygenation levels to thermally noxious stimuli (49°C) will be assessed, and planned comparisons will be performed between subjects trained in mindfulness meditation and those trained in deep-breathing meditation.
次要结局
- Change in Visual Analog Scale Pain Ratings as a function of mindfulness-based mental training(Up to 3 weeks)
研究者
Fadel Zeidan
Assistant Professor
University of California, San Diego