Clinical Features and Outcomes of Continuous Blood Purification Versus Non-continuous Blood Purification in Pediatric Patients With Sepsis or Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- survival rate
研究概览
简要总结
The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored. In this study, we need to explore the efficacy and the timing of application of CBP in children with sepsis or septic shock.
详细描述
Early intervention of CBP can remove inflammatory factors in patients with sepsis and reduce the damage of inflammatory factors to organs; at the same time, it can also promote the body's immune response, significantly improve immune dysfunction, and restore the body's immune balance. However, the timing of early application of CBP in childhood sepsis is still unclear. Therefore, it is necessary to further explore the treatment and prognosis of this technology in the early treatment of sepsis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 28 Days 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age of 29d to 18 years old;
- •Children diagnosed with sepsis requiring blood purification.
排除标准
- •with a history of a duration of PICU stay <24 h
- •active bleeding, including cerebral hemorrhage
研究组 & 干预措施
sepsis group without CBP
The child with sepsis should be treated with CBP and received this treatment
sepsis group with CBP
The child with sepsis should be treated with CBP， but could not receive this treatment for various reasons
干预措施: CBP (Procedure)
结局指标
主要结局
survival rate
时间窗: 28 days after hospital discharge
The survival rate of children in 28 days after hospital discharge
次要结局
- The creatinine level of non-survival children with sepsis(28 days after hospital discharge)